Shahid A, Siddiqui A A, Zuberi S J, Waqar M A
PMRC Research Centre, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.
J Gastroenterol Hepatol. 1993 Nov-Dec;8(6):505-7. doi: 10.1111/j.1440-1746.1993.tb01642.x.
Evaluation of serum alpha 1-antitrypsin levels in the South Asian population and its possible involvement in disease conditions such as duodenal ulcer has not been given due consideration. This is mainly because reports from European and North American countries indicate that the genetic deficiency of this protease inhibitor is rare among Asians of the subcontinent. Using isoelectric focusing (IEF) and radial immunodiffusion (RID) techniques, we analysed serum samples from 100 normal, healthy adults and 50 patients with endoscopically proven duodenal ulcers to determine if there is a possible relationship between alpha 1-antitrypsin phenotype and this disease. Five duodenal ulcer patients had low alpha 1-antitrypsin levels as well as SZ and S phenotype. None of the controls showed presence of S or SZ phenotypes. The normal or most common genetic form, MM, is the predominant phenotype in both controls and patients.
南亚人群血清α1-抗胰蛋白酶水平的评估及其在十二指肠溃疡等疾病中的可能作用尚未得到充分考虑。这主要是因为来自欧洲和北美国家的报告表明，这种蛋白酶抑制剂的基因缺陷在该次大陆的亚洲人中很少见。我们使用等电聚焦（IEF）和放射免疫扩散（RID）技术，分析了100名正常健康成年人和50名经内镜证实为十二指肠溃疡患者的血清样本，以确定α1-抗胰蛋白酶表型与这种疾病之间是否存在可能的关系。5名十二指肠溃疡患者的α1-抗胰蛋白酶水平较低，且存在SZ和S表型。对照组中均未出现S或SZ表型。正常或最常见的基因形式MM，是对照组和患者中的主要表型。
