Department of Oral Medicine and Radiology, Sathyabama Dental College and Hospital, Chennai, Tamil Nadu, India, Phone: +91 7373230303, e-mail:
Department of Oral Medicine and Radiology, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India.
J Contemp Dent Pract. 2020 Aug 1;21(8):884-890.
To evaluate the efficacy of topical curcumin and topical triamcinolone acetonide in a professional population with minor aphthous ulcers by assessing six clinical variables: site, size, pain, healing period, frequency of recurrence and number of ulcers.
This randomized, parallel designed pilot trial was performed on 60 symptomatic individuals with minor aphthous ulcer. Willing participants were allocated randomly into group I and group II. Participants in group I were treated with topical curcumin and group II were treated with topical triamcinolone acetonide for a period of 6 months. All participants were blinded to the drug they received. Participants were assessed on day 1, day 3, day 5, day 7, and after healing for symptomatic reduction in pain, size, healing period, frequency of recurrence, and in the number of ulcers. Statistically, independent sample test, Chi-square test, and Log rank Kaplan-Meier survival analysis were performed.
Lower labial mucosa was found to be the predominant site of minor aphthous ulcer in both the groups. A gradual reduction in pain and size was noted in both the groups with statistical significance of value <0.001. All the ulcers in both the groups healed completely without scarring within 2 weeks with statistical significance. In both the treatment groups, new ulcers occurred throughout the follow-up period of 6 months. The mean number of the ulcers are statistically not significant with value >0.05.
Our study showed clinically beneficial effects with topical curcumin with regard to ulcer size, pain, healing, and recurrence rate. Also topical curcumin gel was well tolerated and performed ot par with topical triamcinolone acetonide oral paste with a borderline favorable result with triamcinolone.
Curcumin can be safely recommended on a long-term basis as a more appealing therapeutic agent and is a better alternative choice for aphthous ulcers in children, pregnant woman, lactating mother, and in immunocompromised individuals.
通过评估 6 个临床变量（部位、大小、疼痛、愈合期、复发频率和溃疡数量），评估局部姜黄素和局部曲安奈德醋酸酯在患有轻度阿弗他溃疡的专业人群中的疗效。
这是一项随机、平行设计的初步试验，共纳入 60 例有症状的轻度阿弗他溃疡患者。愿意参加的患者被随机分为 I 组和 II 组。I 组患者接受局部姜黄素治疗，II 组患者接受局部曲安奈德醋酸酯治疗，为期 6 个月。所有参与者对他们接受的药物均不知情。在第 1 天、第 3 天、第 5 天、第 7 天和愈合后，评估参与者疼痛、大小、愈合期、复发频率和溃疡数量的症状减轻情况。统计学分析采用独立样本 t 检验、卡方检验和对数秩 Kaplan-Meier 生存分析。
两组患者的主要病变部位均为下唇黏膜。两组患者的疼痛和大小均逐渐减轻，差异具有统计学意义（ 值<0.001）。两组患者的所有溃疡均在 2 周内完全愈合，无瘢痕形成，差异具有统计学意义。在两组治疗组中，整个 6 个月的随访期间均出现新的溃疡。两组的平均溃疡数差异无统计学意义（ 值>0.05）。
我们的研究表明，局部姜黄素在溃疡大小、疼痛、愈合和复发率方面具有临床获益。局部姜黄素凝胶也具有良好的耐受性，与曲安奈德醋酸酯口腔糊剂的疗效相当，与曲安奈德相比具有边缘优势。
姜黄素可以作为一种更有吸引力的治疗药物，安全地长期推荐，特别是在儿童、孕妇、哺乳期妇女和免疫功能低下的人群中，是阿弗他溃疡的更好选择。
