School of Basic Medical Sciences, Shanxi University of Chinese Medicine, Jinzhong 030619, Shanxi, PR China.
School of Public Health, Shanxi Medical University, Taiyuan 030001, Shanxi, PR China.
Fungal Genet Biol. 2020 Oct;143:103431. doi: 10.1016/j.fgb.2020.103431. Epub 2020 Jun 28.
Cordyceps genus, such as C. militaris and C. kyushuensis, is a source of a rare traditional Chinese medicine that has been used for the treatment of numerous chronic and malignant diseases. Cordycepin, 3'-deoxyadenosine, is a major active compound found in most Cordyceps. Cordycepin exhibits a variety of biological activities, including anti-tumor, immunomodulation, antioxidant, and anti-aging, among others, which could be applied in health products, medicine, cosmeceutical etc. fields. This review focuses on the synthesis methods for cordycepin. The current methods for cordycepin synthesis involve chemical synthesis, microbial fermentation, in vitro synthesis and biosynthesis; however, some defects are unavoidable and the production is still far from the demand of cordycepin. For the future study of cordycepin synthesis, based on the illumination of cordycepin biosynthesis pathway, genetical engineering of the Cordyceps strain or introducing microbes by virtue of synthetic biology will be the great potential strategies for cordycepin synthesis. This review will aid the future synthesis of the valuable cordycepin.
蛹虫草属，如蛹虫草和蛹虫草，是一种稀有的中药的来源，已被用于治疗许多慢性和恶性疾病。蛹虫草素，3'-脱氧腺苷，是大多数蛹虫草中发现的主要活性化合物。蛹虫草素有多种生物活性，包括抗肿瘤、免疫调节、抗氧化和抗衰老等，可应用于保健品、医药、化妆品等领域。本文综述了蛹虫草素的合成方法。目前蛹虫草素的合成方法包括化学合成、微生物发酵、体外合成和生物合成；然而，不可避免地存在一些缺陷，而且生产仍然远远不能满足蛹虫草素的需求。对于蛹虫草素合成的未来研究，基于蛹虫草素生物合成途径的启示，蛹虫草菌株的基因工程或利用合成生物学引入微生物将是蛹虫草素合成的巨大潜力策略。本文综述将有助于未来有价值的蛹虫草素的合成。
