Molecular and Systems Physiology Laboratory, Gene Expression Laboratory, NOMIS Center for Immunology and Microbial Pathogenesis, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Cell. 2020 Apr 16;181(2):250-269. doi: 10.1016/j.cell.2020.03.036.
The ability to maintain health, or recover to a healthy state after disease, is an active process involving distinct adaptation mechanisms coordinating interactions between all physiological systems of an organism. Studies over the past several decades have assumed the mechanisms of health and disease are essentially inter-changeable, focusing on the elucidation of the mechanisms of disease pathogenesis to enhance health, treat disease, and increase healthspan. Here, I propose that the evolved mechanisms of health are distinct from disease pathogenesis mechanisms and suggest that we develop an understanding of the biology of physiological health. In this Perspective, I provide a definition of, a conceptual framework for, and proposed mechanisms of physiological health to complement our understanding of disease and its treatment.
维持健康的能力，或在患病后恢复健康的能力，是一个涉及到生物体所有生理系统之间相互作用的独特适应机制的主动过程。过去几十年来的研究假设健康和疾病的机制在本质上是可以相互转换的，研究重点是阐明疾病发病机制的机制，以增强健康、治疗疾病和延长健康寿命。在这里，我提出健康的进化机制与疾病发病机制不同，并建议我们对生理健康的生物学有一个理解。在本观点中，我提供了生理健康的定义、概念框架和提出的机制，以补充我们对疾病及其治疗的理解。
