Ike Kevin G O, de Boer Sietse F, Buwalda Bauke, Kas Martien J H
Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, the Netherlands.
Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, the Netherlands.
Neurosci Biobehav Rev. 2020 Sep;116:251-267. doi: 10.1016/j.neubiorev.2020.06.030. Epub 2020 Jun 28.
Social withdrawal is found across neuropsychiatric disorders and in numerous animal species under various conditions. It has substantial impact on the quality of life in patients suffering from neuropsychiatric disorders. Often it occurs prodromal to the disease, suggesting that it is either an early biomarker or central to its etiology. Healthy social functioning is supported by the social brain of which the building blocks go back millions of years, showing overlap between humans, rodents and insects. Thus, to elucidate social withdrawal, we have to approach its environmental triggers and its neural and molecular genetic determinants in an evolutionary context. Pathological social withdrawal may originate from a faulty regulation of specific neural circuits. As there is considerable heritability in social disorders, the genetic building blocks of the social decision making network might be our most relevant target to obtain an understanding of the transition of normal social interaction into social withdrawal.
社交退缩在各种神经精神疾病中都有发现，并且在多种动物物种的不同条件下也存在。它对患有神经精神疾病的患者的生活质量有重大影响。它通常在疾病前驱期出现，这表明它要么是一种早期生物标志物，要么是其病因的核心。健康的社交功能由社交大脑支持，其组成部分可以追溯到数百万年前，显示出人类、啮齿动物和昆虫之间的重叠。因此，为了阐明社交退缩，我们必须在进化背景下探讨其环境触发因素以及神经和分子遗传决定因素。病理性社交退缩可能源于特定神经回路的调节故障。由于社交障碍存在相当大的遗传性，社交决策网络的遗传组成部分可能是我们理解正常社交互动向社交退缩转变的最相关目标。
