强直性脊柱炎、急性前葡萄膜炎与HLA - B27之间的关联：一项瑞士家族研究的结果

The association between ankylosing spondylitis, acute anterior uveitis and HLA-B27: the results of a Swiss family study.

作者信息

van der Linden S M, Rentsch H U, Gerber N, Cats A, Valkenburg H A

机构信息

Department of Clinical Medicine, University Hospital, Maastricht, The Netherlands.

出版信息

Br J Rheumatol. 1988;27 Suppl 2:39-41. doi: 10.1093/rheumatology/xxvii.suppl_2.39.

DOI:10.1093/rheumatology/xxvii.suppl_2.39

PMID:3261189

Abstract

Patients with HLA-B27 positive ankylosing spondylitis (AS) in a Swiss family study developed non-granulomatous acute anterior uveitis (AAU) 11 times more often than their healthy relatives sharing the same HLA-B27 positive haplotype (4.4% versus 0.4%; p less than 0.01) during a period of 6 months.

摘要

在一项瑞士家族研究中，HLA - B27阳性的强直性脊柱炎（AS）患者发生非肉芽肿性急性前葡萄膜炎（AAU）的频率比具有相同HLA - B27阳性单倍型的健康亲属高11倍（6个月期间分别为4.4%和0.4%；p小于0.01）。