Tavazzi Silvia, Origgi Riccardo, Anselmi Martina, Corvino Andrea, Colciago Sara, Fagnola Matteo, Bracco Silvia, Zeri Fabrizio
Department of Materials Science, University of Milano-Bicocca, Milan, Italy.
Research Centre in Optics and Optometry (COMiB), University of Milano-Bicocca, Milan, Italy.
Clin Optom (Auckl). 2020 Jun 25;12:75-84. doi: 10.2147/OPTO.S249078. eCollection 2020.
To compare the effects of artificial tears (ATs) in wearers of biweekly replacement silicone hydrogel contact lenses (BW-Ws) and wearers of daily disposable contact lenses (DD-Ws) of the same material.
The aqueous-supplementing ATs, OPTOyalA and OPTOidro, were assigned to be used for 2 weeks to healthy and young subjects: 1) 20 (8 and 12, respectively) BW-Ws wearing silicone hydrogel somofilcon A CLs (Clariti Elite), 2) 18 (9 and 9, respectively) DD-Ws wearing silicone hydrogel somofilcon A CLs (Clarity 1 Day), and 3) a control group of 33 (16 and 17, respectively) N-Ws. Ocular symptoms and comfort, tear volume and stability, and ocular surface condition were assessed by Ocular Surface Disease Index (OSDI), 5-Item Dry Eye Questionnaire (DEQ5), tear meniscus height (TMH), non-invasive tear break-up time (NIBUT), and evaluation of ocular redness (OR). The assessment was performed before and after 15 days of use of the ATs in the 3 groups (BW-Ws, DD-Ws, and N-Ws).
No clear significant difference was noted in symptoms and signs between OPTOyalA and OPTOidro irrespectively of the group of people studied. ATs use for 15 days produced a significant improvement in DEQ5 and OR in DD-Ws (Δ=-34%, p=0.006; Δ=-23%, p<0.001) and in N-Ws (Δ=-21%, p=0.001; Δ=-10%, p=0.006) but not in BW-Ws (Δ=-5%, p=0.072; Δ=-2%, p=0.257). No significant change was noted for TMH.
In young and healthy subjects, the aqueous-supplementing effect of the ATs under consideration is more a rinsing and tear replacem ent effect than an increase in tear volume, and it produces an improvement of the eye redness and ocular symptoms. Contact lens wear influenced the effectiveness of ATs in a way which is correlated with the CL replacement schedule.
比较人工泪液（ATs）对每两周更换一次的硅水凝胶隐形眼镜佩戴者（BW-Ws）和佩戴相同材料日抛型隐形眼镜的佩戴者（DD-Ws）的影响。
将补充水分的人工泪液OPTOyalA和OPTOidro分配给健康的年轻受试者使用2周：1）20名（分别为8名和12名）佩戴硅水凝胶somofilcon A隐形眼镜（Clariti Elite）的BW-Ws，2）18名（分别为9名和9名）佩戴硅水凝胶somofilcon A隐形眼镜（Clarity 1 Day）的DD-Ws，以及3）33名（分别为16名和17名）不佩戴隐形眼镜的人组成的对照组（N-Ws）。通过眼表疾病指数（OSDI）、5项干眼问卷（DEQ5）、泪河高度（TMH）、非侵入性泪膜破裂时间（NIBUT）和眼部发红评估（OR）来评估眼部症状和舒适度、泪液量和稳定性以及眼表状况。在3组（BW-Ws、DD-Ws和N-Ws）使用人工泪液15天前后进行评估。
无论所研究的人群组如何，OPTOyalA和OPTOidro在症状和体征方面均未观察到明显的显著差异。使用人工泪液15天在DD-Ws（Δ=-34%，p=0.006；Δ=-23%，p<0.001）和N-Ws（Δ=-21%，p=0.001；Δ=-10%，p=0.006）中使DEQ5和OR有显著改善，但在BW-Ws中未改善（Δ=-5%，p=0.072；Δ=-2%，p=0.257）。TMH未观察到显著变化。
在年轻健康受试者中，所考虑的人工泪液的补充水分作用更多的是冲洗和泪液替代作用，而非增加泪液量，并且它能改善眼部发红和眼部症状。隐形眼镜佩戴以与隐形眼镜更换时间表相关的方式影响人工泪液的有效性。
