Department of Pharmaceutical Sciences, Guru Gobind Singh College of Pharmacy, Yamuna Nagar 135001, Haryana, India.
Recent Pat Anticancer Drug Discov. 2020;15(2):132-142. doi: 10.2174/1574892815666200702142601.
Arnica montana, containing helenalin as its principal active constituent, is the most widely used plant to treat various ailments. Recent studies indicate that Arnica and helenalin provide significant health benefits, including anti-inflammatory, neuroprotective, antioxidant, cholesterol-lowering, immunomodulatory, and most important, anti-cancer properties.
The objective of the present study is to overview the recent patents of Arnica and its principal constituent helenalin, including new methods of isolation, and their use in the prevention of cancer and other ailments.
Current prose and patents emphasizing the anti-cancer potential of helenalin and Arnica, incorporated as anti-inflammary agents in anti-cancer preparations, have been identified and reviewed with particular emphasis on their scientific impact and novelty.
Helenalin has shown its anti-cancer potential to treat multiple types of tumors, both in vitro and in vivo. It has also portrayed synergistic effects when given in combination with other anti- cancer drugs or natural compounds. New purification/isolation techniques are also developing with novel helenalin formulations and its synthetic derivatives have been developed to increase its solubility and bioavailability.
The promising anti-cancer potential of helenalin in various preclinical studies may open new avenues for therapeutic interventions in different tumors. Thus clinical trials validating its tumor suppressing and chemopreventive activities, particularly in conjunction with standard therapies, are immediately required.
山金车，含有白头翁素作为其主要活性成分，是最广泛用于治疗各种疾病的植物。最近的研究表明，山金车和白头翁素提供了显著的健康益处，包括抗炎、神经保护、抗氧化、降低胆固醇、免疫调节，最重要的是，抗癌特性。
本研究的目的是综述山金车及其主要成分白头翁素的最新专利，包括新的分离方法，以及它们在预防癌症和其他疾病中的应用。
目前强调白头翁素和山金车的抗癌潜力的散文和专利，作为抗炎剂纳入抗癌制剂中，已经被确定并进行了审查，特别强调了它们的科学影响和新颖性。
白头翁素已显示出其抗癌潜力，可治疗多种类型的肿瘤，无论是在体外还是体内。当与其他抗癌药物或天然化合物联合使用时，它也表现出协同作用。新的纯化/分离技术也在发展，具有新的白头翁素配方和其合成衍生物已被开发，以提高其溶解度和生物利用度。
在各种临床前研究中，白头翁素具有有希望的抗癌潜力，可能为不同肿瘤的治疗干预开辟新途径。因此，立即需要进行验证其肿瘤抑制和化学预防活性的临床试验，特别是与标准疗法联合使用。
