Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
Department of Internal Medicine, Dongguk University College of Medicine, Gyeongju, Korea.
Endocrinol Metab (Seoul). 2020 Jun;35(2):480-483. doi: 10.3803/EnM.2020.35.2.480. Epub 2020 Jun 24.
We investigated proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations in individuals with normoglycemia, impaired fasting glucose (IFG), and impaired glucose tolerance (IGT). This was a pilot, cross-sectional study including 92 individuals who had not been diagnosed with or treated for diabetes. We measured PCSK9 levels in three groups of subjects; namely, normoglycemia (n=57), IFG (n=21), and IGT (n=14). Individuals with IFG and IGT showed higher PCSK9 concentrations than those in the normoglycemic group, with the highest serum PCSK9 concentrations found in individuals with IGT (55.25±15.29 ng/mL for normoglycemia, 63.47±17.78 ng/mL for IFG, 72.22±15.46 ng/mL for IGT, analysis of variance P=0.001). There were no significant differences in high- or low-density lipoprotein cholesterol among groups. Serum PCSK9 levels are increased in patients with prediabetes compared to subjects with normoglycemia.
我们研究了空腹血糖正常、空腹血糖受损（IFG）和糖耐量受损（IGT）个体的前蛋白转化酶枯草溶菌素/ kexin 9（PCSK9）浓度。这是一项包括 92 名未被诊断或治疗为糖尿病的个体的试点、横断面研究。我们在三组受试者中测量了 PCSK9 水平：空腹血糖正常组（n=57）、IFG 组（n=21）和 IGT 组（n=14）。IFG 和 IGT 患者的 PCSK9 浓度高于空腹血糖正常组，IGT 患者的血清 PCSK9 浓度最高（空腹血糖正常组为 55.25±15.29ng/ml，IFG 组为 63.47±17.78ng/ml，IGT 组为 72.22±15.46ng/ml，方差分析 P=0.001）。各组之间的高密度脂蛋白胆固醇或低密度脂蛋白胆固醇没有显著差异。与空腹血糖正常者相比，糖尿病前期患者的血清 PCSK9 水平升高。
