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病例报告-艾滋病毒阳性患者的免疫恢复性后巩膜炎。

Case report-immune recovery posterior scleritis in a HIV positive patient.

机构信息

Department of Ophthalmology, Huashan Hospital of Fudan University, No. 12, Middle Urumqi Road, Shanghai, 200040, China.

出版信息

BMC Ophthalmol. 2020 Jul 2;20(1):262. doi: 10.1186/s12886-020-01529-3.

DOI:10.1186/s12886-020-01529-3
PMID:32615955
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7330949/
Abstract

BACKGROUND

Posterior scleritis is an uncommon vision-threatening disorder that is often recurrent and difficult to cure due to its complex etiology. In HIV patients, posterior scleritis may develop several months after significant rise in CD4+ T-lymphocyte, even after several years, which may be diagnosed as late-onset immune recovery scleritis.

CASE PRESENTATION

Here we report a case of posterior scleritis in a HIV positive patient who presented with severe periocular pain and decreased vision in the left eye, with exudative retinal detachment and optic nerve involvement.

CONCLUSIONS

Early differential diagnosis of immune recovery posterior scleritis and intensive corticosteroids treatment, can prevent vision loss effectively in HIV patients.

摘要

背景

后巩膜炎是一种罕见的威胁视力的疾病,由于其复杂的病因,常反复发作,难以治愈。在 HIV 患者中,后巩膜炎可在 CD4+T 淋巴细胞显著升高后数月,甚至数年后发生,可能被诊断为迟发性免疫重建后巩膜炎。

病例介绍

我们在此报告一例 HIV 阳性患者的后巩膜炎病例,该患者左眼出现严重的眶周疼痛和视力下降,伴有渗出性视网膜脱离和视神经受累。

结论

早期对免疫重建后巩膜炎进行鉴别诊断并进行强化皮质类固醇治疗,可以有效预防 HIV 患者的视力丧失。

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本文引用的文献

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Tubercular posterior scleritis: A case report and review of literature.结核性后巩膜炎:病例报告及文献复习。
Indian J Ophthalmol. 2019 Aug;67(8):1362-1365. doi: 10.4103/ijo.IJO_1942_18.
2
Cryopyrin-associated periodic syndrome presenting with posterior scleritis.伴有后巩膜炎的冷吡啉相关周期性综合征
Rheumatology (Oxford). 2019 Dec 1;58(12):2337-2339. doi: 10.1093/rheumatology/kez197.
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Infective conjunctivitis progressing to posterior scleritis.感染性结膜炎进展为后巩膜炎。
Clin Exp Ophthalmol. 2019 Aug;47(6):795-796. doi: 10.1111/ceo.13503. Epub 2019 Apr 15.
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Atypical posterior scleritis mimicking choroidal melanoma.酷似脉络膜黑色素瘤的非典型后巩膜炎。
Saudi Med J. 2018 May;39(5):514-518. doi: 10.15537/smj.2018.5.22130.
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Severe Idiopathic Posterior Scleritis in a Patient with HIV.一名艾滋病患者的严重特发性后巩膜炎
Klin Monbl Augenheilkd. 2017 Apr;234(4):571-574. doi: 10.1055/s-0042-122442. Epub 2017 Feb 1.
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Clinical Features and Complications of Scleritis in Chinese Patients.中国患者巩膜炎的临床特征和并发症。
Ocul Immunol Inflamm. 2018;26(3):387-396. doi: 10.1080/09273948.2016.1241282. Epub 2016 Nov 16.
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Immune recovery uveitis: pathogenesis, clinical symptoms, and treatment.免疫恢复性葡萄膜炎:发病机制、临床症状及治疗
Mediators Inflamm. 2014;2014:971417. doi: 10.1155/2014/971417. Epub 2014 Jun 24.
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Clinical features and presentation of posterior scleritis: a report of 31 cases.后巩膜炎的临床特征与表现:31例报告
Ocul Immunol Inflamm. 2014 Jun;22(3):203-7. doi: 10.3109/09273948.2013.840385. Epub 2013 Oct 16.
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Management of the immune reconstitution inflammatory syndrome.免疫重建炎症综合征的管理。
Curr HIV/AIDS Rep. 2012 Sep;9(3):238-50. doi: 10.1007/s11904-012-0129-5.
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Long-term, multicenter evaluation of subconjunctival injection of triamcinolone for non-necrotizing, noninfectious anterior scleritis.长期、多中心评估曲安奈德结膜下注射治疗非坏死性、非感染性前部巩膜炎。
Ophthalmology. 2011 Oct;118(10):1932-7. doi: 10.1016/j.ophtha.2011.02.043. Epub 2011 Jun 25.