Human Reproduction Department, IVI-RMA Valencia, Plaza Policía Local, 3, 46015, Spain; IVI RMA Foundation, Research, Valencia, Spain.
Human Reproduction Department, IVI-RMA Valencia, Plaza Policía Local, 3, 46015, Spain; Biomedical Research Institute La FE, Research, Valencia, Spain.
Best Pract Res Clin Obstet Gynaecol. 2020 Nov;69:74-84. doi: 10.1016/j.bpobgyn.2020.05.005. Epub 2020 Jun 4.
Progesterone is the main hormone in the luteal phase. It plays a key role in preparing the uterus for a possible pregnancy, and in maintaining it after it has occurred. In assisted reproduction treatments, there is usually a luteal phase deficiency, so it is necessary to supplement this critical phase to obtain the best results, not only of implantation but also of ongoing pregnancy. Among all the available options, exogenously administered progestogens are the most used, as they have proven their efficacy and safety. This review will address the most relevant aspects of luteal phase support with progesterone in the different scenarios an embryo transfer can be performed, such as the stimulated cycle, the artificial cycle, or the natural cycle. Although there is no evidence of the perfect protocol for all patients, recent studies point to the need of individualizing luteal phase support according to the needs of each patient.
孕激素是黄体期的主要激素。它在为可能的怀孕做准备子宫方面起着关键作用，并在怀孕发生后维持它。在辅助生殖治疗中，通常存在黄体期不足，因此有必要补充这个关键阶段，以获得最佳效果，不仅是着床，还有持续妊娠。在所有可用的选择中，外源性孕激素是最常用的，因为它们已经证明了它们的疗效和安全性。这篇综述将讨论胚胎移植可以在不同情况下进行时，用孕激素支持黄体期的最相关方面，如刺激周期、人工周期或自然周期。虽然没有证据表明所有患者都有完美的方案，但最近的研究表明，根据每个患者的需求，黄体期支持需要个体化。
