Department of Environmental Sciences, University of California, Riverside, California 92521, United States.
Department of Chemical and Environmental Engineering, University of California, Riverside, California 92521, United States.
Chem Res Toxicol. 2020 Aug 17;33(8):2157-2163. doi: 10.1021/acs.chemrestox.0c00174. Epub 2020 Jul 17.
Recent reports have linked severe lung injuries and deaths to the use of e-cigarettes and vaping products. Nevertheless, the causal relationship between exposure to vaping emissions and the observed health outcomes remains to be elucidated. Through chemical and toxicological characterization of vaping emission products, this study demonstrates that during vaping processes, changes in chemical composition of several commonly used vape juice diluents (also known as cutting agents) lead to the formation of toxic byproducts, including quinones, carbonyls, esters, and alkyl alcohols. The resulting vaping emission condensates cause inhibited cell proliferation and enhanced cytotoxicity in human airway epithelial cells. Notably, substantial formation of the duroquinone and durohydroquinone redox couple was observed in the vaping emissions from vitamin E acetate, which may be linked to acute oxidative stress and lung injuries reported by previous studies. These findings provide an improved molecular understanding and highlight the significant role of toxic byproducts in vaping-associated health effects.
最近的报告将严重的肺部损伤和死亡与使用电子烟和蒸气产品联系起来。然而，暴露于蒸气排放物和观察到的健康结果之间的因果关系仍有待阐明。通过对蒸气排放物产品的化学和毒理学表征，本研究表明，在蒸气过程中，几种常用蒸气液稀释剂（也称为切割剂）的化学成分变化导致有毒副产物的形成，包括醌、羰基化合物、酯和烷基醇。由此产生的蒸气排放冷凝物导致人呼吸道上皮细胞增殖受到抑制和细胞毒性增强。值得注意的是，在维生素 E 醋酸盐的蒸气排放物中观察到大量的二醌和二氢醌氧化还原对的形成，这可能与以前的研究报告的急性氧化应激和肺部损伤有关。这些发现提供了对分子的更好理解，并强调了有毒副产物在蒸气相关健康影响中的重要作用。
