Romero R W, Nesbitt L T, Reed R J
Arch Dermatol. 1977 Jun;113(6):741-8.
Eleven patients with a skin disorder in which clinical, histopathologic, and immunofluorescent findings showed overlap features of both lupus erythematosus (LE) and lichen planus (LP) were observed for several years. Clinical lesions were extremely long-term and consisted primarily of livid red to violaceous atrophic patches and plaques, most common on acral aspects of the extremities. Nails were also commonly involved, often showing anonychia. Histologic changes combined cell-rich and cell-poor lichenoid patterns in the papillary dermis, suggesting both LP and LE. The major immunofluorescent finding in all patients was the presence of ovoid bodies at the dermal-epidermal (D-E) junction and in the upper dermis. Most patients showed both a linear arrangement and a clustering pattern of these bodies. Four patients also had coexistant but poorly developed linear deposits of immunoglobulins and complement at the D-E junction.
观察了11例患有皮肤疾病的患者数年，其临床、组织病理学和免疫荧光检查结果显示同时具有红斑狼疮（LE）和扁平苔藓（LP）的重叠特征。临床损害持续时间极长，主要由青紫色至紫红色的萎缩性斑片和斑块组成，最常见于四肢末端。指甲也常受累，常表现为甲缺失。组织学改变在乳头层真皮中合并了细胞丰富和细胞稀少的苔藓样模式，提示同时存在LP和LE。所有患者免疫荧光检查的主要发现是在真皮表皮（D-E）交界处和真皮上层存在卵圆形小体。大多数患者这些小体呈线性排列和聚集模式。4例患者在D-E交界处还同时存在但发育不良的免疫球蛋白和补体线性沉积。
