CD4+滤泡辅助性T细胞与CD8+组织驻留记忆T细胞之间的关系：姐妹还是远亲？
The relationship between CD4+ follicular helper T cells and CD8+ resident memory T cells: sisters or distant cousins?
作者信息
Peng Changwei, Jameson Stephen C
机构信息
Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, USA.
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA.
出版信息
Int Immunol. 2020 Sep 8;32(9):583-587. doi: 10.1093/intimm/dxaa045.
Abstract
Independent studies over the last decade have characterized the properties of non-circulating CD8+ 'resident' memory T cells (TRM), which offer barrier protective immunity in non-lymphoid tissues and CD4+ follicular helper T cells (TFH), which mediate B-cell help in lymphoid sites. Despite their very different biological roles in the immune system, intriguing parallels have been noted between the trafficking properties and differentiation cues of these populations, parallels which have only sharpened with recent findings. In this review, we explore the features that underlie these similarities and discuss whether these indicate meaningful homologies in the development of CD8+ TRM and CD4+ TFH or reflect resemblances which are only 'skin-deep'.
摘要
过去十年的独立研究已经描述了非循环性CD8⁺“组织驻留”记忆T细胞（TRM）的特性，这类细胞在非淋巴组织中提供屏障保护性免疫；以及CD4⁺滤泡辅助性T细胞（TFH）的特性，这类细胞在淋巴部位介导对B细胞的辅助。尽管它们在免疫系统中的生物学作用截然不同，但人们已经注意到这些细胞群体在迁移特性和分化线索方面存在有趣的相似之处，而且随着最近的研究发现，这些相似之处变得更加明显。在这篇综述中，我们探讨了构成这些相似性的基础特征，并讨论这些特征是否表明CD8⁺TRM和CD4⁺TFH在发育过程中存在有意义的同源性，或者只是反映了表面上的相似性。
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