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1
Species-specific TNF induction of thymocyte proliferation.物种特异性肿瘤坏死因子诱导胸腺细胞增殖。
Cancer Immunol Immunother. 1988;27(2):103-8. doi: 10.1007/BF00200012.
2
Role of endogenously produced interleukin-6 as a second signal in murine thymocyte proliferation induced by multiple cytokines: regulatory effects of transforming growth factor-beta.内源性产生的白细胞介素-6作为多种细胞因子诱导小鼠胸腺细胞增殖的第二信号的作用：转化生长因子-β的调节作用
Cell Immunol. 1990 Dec;131(2):261-71. doi: 10.1016/0008-8749(90)90253-n.
3
Role of tumor necrosis factor and interleukin 1 in gamma-interferon-promoted activation of mouse tumoricidal macrophages.肿瘤坏死因子和白细胞介素1在γ-干扰素促进的小鼠杀肿瘤巨噬细胞激活中的作用
Cancer Res. 1989 May 15;49(10):2606-14.
4
Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation.肿瘤坏死因子的免疫功能。I. 肿瘤坏死因子诱导小鼠胸腺细胞凋亡，并且根据促有丝分裂共刺激的浓度，还可刺激或抑制白细胞介素-6诱导的增殖。
J Immunol. 1993 Oct 15;151(8):3999-4012.
5
Both interleukin 1 and tumor necrosis factor enhance thymocyte proliferation.白细胞介素1和肿瘤坏死因子均可增强胸腺细胞的增殖。
Eur J Immunol. 1988 Aug;18(8):1303-6. doi: 10.1002/eji.1830180824.
6
Synergism of interleukin 7 with the thymocyte growth factors interleukin 2, interleukin 6, and tumor necrosis factor alpha in the induction of thymocyte proliferation.白细胞介素7与胸腺细胞生长因子白细胞介素2、白细胞介素6及肿瘤坏死因子α在诱导胸腺细胞增殖中的协同作用。
Cell Immunol. 1990 May;127(2):470-82. doi: 10.1016/0008-8749(90)90147-j.
7
Growth-promoting activity of IL-1 alpha, IL-6, and tumor necrosis factor-alpha in combination with IL-2, IL-4, or IL-7 on murine thymocytes. Differential effects on CD4/CD8 subsets and on CD3+/CD3- double-negative thymocytes.白细胞介素-1α、白细胞介素-6和肿瘤坏死因子-α与白细胞介素-2、白细胞介素-4或白细胞介素-7联合对小鼠胸腺细胞的促生长活性。对CD4/CD8亚群和CD3+/CD3-双阴性胸腺细胞的不同影响。
J Immunol. 1990 Apr 15;144(8):3039-45.
8
The two different receptors for tumor necrosis factor mediate distinct cellular responses.肿瘤坏死因子的两种不同受体介导不同的细胞反应。
Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9292-6. doi: 10.1073/pnas.88.20.9292.
9
IL-7 is requisite for IL-1-induced thymocyte proliferation. Involvement of IL-7 in the synergistic effects of granulocyte-macrophage colony-stimulating factor or tumor necrosis factor with IL-1.白细胞介素-7是白细胞介素-1诱导胸腺细胞增殖所必需的。白细胞介素-7参与粒细胞-巨噬细胞集落刺激因子或肿瘤坏死因子与白细胞介素-1的协同效应。
J Immunol. 1992 Jan 1;148(1):99-105.
10
Comparative effects of tumor necrosis factor-alpha and IL-1 beta on mitogen-induced T cell activation.肿瘤坏死因子-α和白细胞介素-1β对丝裂原诱导的T细胞活化的比较作用。
J Immunol. 1988 Apr 15;140(8):2639-44.

引用本文的文献

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Doxorubicin induces specific immune functions and cytokine expression in peritoneal cells.阿霉素可诱导腹膜细胞产生特定免疫功能并表达细胞因子。
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2
Production of tumor necrosis factor-alpha and lymphotoxin by cells of Hodgkin's neoplastic cell lines HDLM-1 and KM-H2.霍奇金氏肿瘤细胞系HDLM-1和KM-H2的细胞产生肿瘤坏死因子-α和淋巴毒素。
Am J Pathol. 1989 Oct;135(4):735-45.
3
The two different receptors for tumor necrosis factor mediate distinct cellular responses.肿瘤坏死因子的两种不同受体介导不同的细胞反应。
Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9292-6. doi: 10.1073/pnas.88.20.9292.
4
Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma.人肿瘤坏死因子受体p75在转染的大鼠/小鼠T细胞杂交瘤中的功能特性研究
J Exp Med. 1992 Oct 1;176(4):1015-24. doi: 10.1084/jem.176.4.1015.

本文引用的文献

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Induction of receptors for interleukin 2 requires T cell Ag:Ia receptor crosslinking and interleukin 1.白细胞介素2受体的诱导需要T细胞抗原：Ia受体交联和白细胞介素1。
Lymphokine Res. 1984 Summer;3(4):175-82.
2
Preparation of goat antibodies against interleukin 1: use of an immunoadsorbent to purify interleukin 1.抗白细胞介素1山羊抗体的制备：使用免疫吸附剂纯化白细胞介素1。
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Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro.重组人肿瘤坏死因子-α：对体外正常细胞和转化细胞增殖的影响
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Cloning and expression in Escherichia coli of the gene for human tumour necrosis factor.人类肿瘤坏死因子基因在大肠杆菌中的克隆与表达。
Nature. 1985;313(6005):803-6. doi: 10.1038/313803a0.
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Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.转化生长因子β对细胞毒性T细胞发育的抑制作用及重组肿瘤坏死因子α的逆转作用。
J Exp Med. 1987 Oct 1;166(4):991-8. doi: 10.1084/jem.166.4.991.
6
Effects of human interleukin 1 and human tumor necrosis factor on human T lymphocyte colony formation.人白细胞介素1和人肿瘤坏死因子对人T淋巴细胞集落形成的影响。
J Clin Invest. 1987 Sep;80(3):772-7. doi: 10.1172/JCI113133.
7
Synergistic stimulation of fibroblast prostaglandin production by recombinant interleukin 1 and tumor necrosis factor.重组白细胞介素1与肿瘤坏死因子对成纤维细胞前列腺素产生的协同刺激作用。
J Immunol. 1987 Jun 1;138(11):3812-6.
8
Growth-promoting effect of recombinant interleukin 1 and tumor necrosis factor for a human astrocytoma cell line.重组白细胞介素1和肿瘤坏死因子对人星形细胞瘤细胞系的促生长作用
J Immunol. 1987 May 1;138(9):2913-6.
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Enhancement of antigen- and mitogen-induced human T lymphocyte proliferation by tumor necrosis factor-alpha.
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B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes.B细胞刺激因子-2参与细胞毒性T淋巴细胞的分化。
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物种特异性肿瘤坏死因子诱导胸腺细胞增殖。

Species-specific TNF induction of thymocyte proliferation.

作者信息

Ehrke M J, Ho R L, Hori K

机构信息

Grace Cancer Drug Center, Roswell Park Memorial Institute, Buffalo, NY 14263.

出版信息

Cancer Immunol Immunother. 1988;27(2):103-8. doi: 10.1007/BF00200012.

DOI:10.1007/BF00200012
PMID:3262011
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11038300/
Abstract

Recombinant murine (rMu) tumor necrosis factor (TNF), in a standard comitogenic assay with phytohemagglutinin, induced murine thymocyte proliferation, while up to 10,000-fold higher concentrations of recombinant human TNF did not. The induction of thymocyte proliferation was dependent upon TNF concentration in a biphasic manner. Thus, 100 to 1,000 units/ml TNF were near optimal while concentrations greater than or equal to 1,000 units/ml caused apparent down regulation. The effect was abrogated by neutralizing antibody to rMu-TNF but not by neutralizing antibody to rMu-interleukin 1 alpha or beta. The rMu-TNF did not induce proliferation of the mature murine T-helper cell line, D10.G4.1, in the presence of mitogen. Taken together the results indicate that TNF, in a strictly species-specific manner, can regulate thymocyte proliferation independently of interleukin 1.

摘要

在与植物血凝素的标准促有丝分裂试验中，重组鼠（rMu）肿瘤坏死因子（TNF）可诱导鼠胸腺细胞增殖，而浓度高达其10000倍的重组人TNF却不能。胸腺细胞增殖的诱导以双相方式依赖于TNF浓度。因此，100至1000单位/毫升的TNF接近最佳浓度，而浓度大于或等于1000单位/毫升则会导致明显的下调。该效应可被抗rMu-TNF的中和抗体消除，但不能被抗rMu-白细胞介素1α或β的中和抗体消除。在有丝分裂原存在的情况下，rMu-TNF不会诱导成熟鼠T辅助细胞系D10.G4.1增殖。综合这些结果表明，TNF能够以严格的物种特异性方式独立于白细胞介素1调节胸腺细胞增殖。