Laboratorio "Autofagia y Metabolismo", Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain; Departamento de Biología Funcional, Universidad de Oviedo, Oviedo, Spain.
Laboratorio "Autofagia y Metabolismo", Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain; Departamento de Biología Funcional, Universidad de Oviedo, Oviedo, Spain.
Prog Mol Biol Transl Sci. 2020;172:257-291. doi: 10.1016/bs.pmbts.2020.02.003. Epub 2020 Feb 29.
During the last decades, the potential harmfulness derived from the exposure to environmental pollutants has been largely demonstrated, with associated damages ranging from geno- and cyto-toxicity to tissue malfunction and alterations in organism physiology. Autophagy is an evolutionarily-conserved cellular mechanism essential for cellular homeostasis, which contributes to protect cells from a wide variety of intracellular and extracellular stressors. Due to its pivotal importance, its correct functioning is directly linked to cell, tissue and organismal fitness. Environmental pollutants, particularly industrial compounds, are able to impact autophagic flux, either by increasing it as a protective response, by blocking it, or by switching its protective role toward a pro-cell death mechanism. Thus, the understanding of the effects of chemicals exposure on autophagy has become highly relevant, offering new potential approaches for risk assessment, protection and preventive measures to counteract the detrimental effects of environmental pollutants on human health.
在过去的几十年中，人们已经充分证明了暴露于环境污染物可能带来的危害性，相关损害范围从基因毒性和细胞毒性到组织功能障碍以及生物体生理功能改变。自噬是一种进化上保守的细胞机制，对于细胞稳态至关重要，有助于保护细胞免受各种细胞内和细胞外应激源的侵害。由于其至关重要的作用，其正确的功能与细胞、组织和生物体的适应性直接相关。环境污染物，特别是工业化合物，能够影响自噬流，其方式包括增加自噬以作为一种保护反应、阻断自噬，或者将其保护作用转变为促进细胞死亡的机制。因此，了解化学物质暴露对自噬的影响变得非常重要，为风险评估、保护和预防措施提供了新的潜在方法，以对抗环境污染物对人类健康的有害影响。
