Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
Anticancer Res. 2020 Jul;40(7):3707-3712. doi: 10.21873/anticanres.14359.
BACKGROUND/AIM: Oral cancer incidence is highest worldwide in Taiwan, and practical markers for personalized therapeutic strategies such as immunotherapies, is lacking. Interleukin-12 (IL12) is a cytokine that is reported to exhibit potent tumoricidal effects, however, its genotypic contribution to oral cancer is still largely unknown. We aimed to examine whether IL12A rs568408 and rs2243115 genotypes are associated with oral cancer risk in Taiwan.
Genotypic characteristics of IL12A were determined among 958 oral cancer cases and age- and gender-matched individuals via typical polymerase chain reaction-restriction fragment length polymorphism methodology.
The variant genotypes of IL12A rs568408 and rs2243115 were not found to be significantly associated with elevated oral cancer risk (all p>0.05). Moreover, there was no interaction between IL12A genotypes and personal smoking, alcohol drinking and betel quid chewing behaviors (all p>0.05).
IL12A rs568408 and rs2243115 genotypes may not serve as good predictors for oral cancer risk.
背景/目的：全世界口腔癌发病率最高的地区是中国台湾，而针对免疫疗法等个性化治疗策略，缺乏实用的标志物。白细胞介素 12（IL12）是一种细胞因子，据报道具有很强的杀肿瘤作用，但它的基因型对口腔癌的贡献在很大程度上仍不清楚。我们旨在研究 IL12A rs568408 和 rs2243115 基因型是否与台湾的口腔癌风险相关。
通过典型的聚合酶链反应-限制性片段长度多态性方法，在 958 例口腔癌病例和年龄及性别匹配的个体中确定了 IL12A 的基因型特征。
IL12A rs568408 和 rs2243115 的变异基因型与口腔癌风险升高无显著相关性（均 P>0.05）。此外，IL12A 基因型与个人吸烟、饮酒和嚼槟榔行为之间无交互作用（均 P>0.05）。
IL12A rs568408 和 rs2243115 基因型可能不能作为口腔癌风险的良好预测因子。
