Segal B N, Katsarkas A
Department of Otolaryngology, Sir Mortimer B. Davis-Jewish General Hospital, Montréal, Québec, Canada.
Acta Otolaryngol. 1988 Jul-Aug;106(1-2):102-10. doi: 10.3109/00016488809107376.
Brief whole-body movements (+/- 5 to 170 degrees/s peak velocity; approximately equal to 0.5 s duration), applied during 1.44-s intervals of total darkness while subjects "looked" at a just-viewed target, were used to examine vestibulo-ocular function in 3 patients who had compensated to total unilateral loss of peripheral vestibular function. We found that the combined effects of slow-phase and saccadic eye movements both tended to keep the eyes stabilized on the unseen target. Compensatory slow-phases elicited during rapid head movements ipsilateral to (i.e., towards) the lesion were only about 60% as effective as those elicited during rapid contralateral movements. Compensatory gaze-correcting saccades tended to supplement deficient slow-phase movements, especially during rapid ipsilateral head movement. However, the gaze-correcting effect of saccades was only about half of the required for perfect stabilization. Thus, two functional vestibular deficits were observed during rapid ipsilateral head movements: (1) reduced slow-phase stabilization, and (2) reduced saccadic ability to adequately supplement the deficient slow phases. However, overall vestibular functional capability, as assessed by observation of the net effect of both slow phases and saccades, was much better than would be indicated by conventional observation of slow-phase movements alone.
在完全黑暗的环境中，当受试者“注视”刚看过的目标时，在1.44秒的间隔内施加短暂的全身运动（峰值速度为±5至170度/秒；持续时间约为0.5秒），以检查3例已代偿外周前庭功能完全单侧丧失的患者的前庭眼反射功能。我们发现，慢相和扫视眼动的联合作用都倾向于使眼睛稳定在看不见的目标上。在向病变侧（即朝向病变侧）快速头部运动期间引发的代偿性慢相，其有效性仅为对侧快速运动期间引发的慢相的约60%。代偿性注视校正扫视倾向于补充不足的慢相运动，尤其是在同侧快速头部运动期间。然而，扫视的注视校正效果仅约为完美稳定所需效果的一半。因此，在同侧快速头部运动期间观察到两种功能性前庭缺陷：（1）慢相稳定能力降低，（2）扫视补充不足慢相的能力降低。然而，通过观察慢相和扫视的净效应评估的整体前庭功能能力，比仅通过传统的慢相运动观察所表明的要好得多。
