Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, H-1111 Budapest, Hungary.
Budapest University of Technology and Economics, Department of Organic Chemistry and Technology, H-1111 Budapest, Hungary.
Int J Pharm. 2020 Aug 30;586:119593. doi: 10.1016/j.ijpharm.2020.119593. Epub 2020 Jul 2.
The effect of different frequencies and waveforms was investigated for the first time on alternating current electrospinning (ACES). PVPVA64, a polyvinylpyrrolidone-vinyl acetate copolymer was selected for the experiments as an important matrix for amorphous solid dispersions but never processed with ACES. It has been proved that ACES could be operated in a wide range of frequencies (40-250 Hz) and using different waveforms (sinusoidal, square, triangle, saw tooth) without significant changes in fiber morphology. Nevertheless, deterioration of the fiber formation process could be also observed especially at high frequencies. The developed PVPVA64-based fibers containing small amounts of additives (polyethylene oxide (PEO) and sodium dodecyl sulfate (SDS)) served as an excellent carrier for spironolactone (SPIR), a poorly soluble antihypertensive drug. As a result of the amorphously dispersed SPIR and the large surface area of the AC electrospun fibers immediate drug release could be achieved.
首次研究了不同频率和波形对交流电静电纺丝（ACES）的影响。PVPVA64 是一种聚乙烯吡咯烷酮-醋酸乙烯共聚物，被选为实验中的重要无定形固体分散基质，但从未使用 ACES 进行处理。已经证明，ACES 可以在很宽的频率范围内（40-250 Hz）和使用不同的波形（正弦波、方波、三角波、锯齿波）下运行，而纤维形态没有明显变化。然而，在高频下也可以观察到纤维形成过程的恶化。开发的基于 PVPVA64 的纤维含有少量添加剂（聚环氧乙烷（PEO）和十二烷基硫酸钠（SDS）），可用作难溶性抗高血压药物螺内酯（SPIR）的优良载体。由于 SPIR 无定形分散和 AC 静电纺丝纤维的大表面积，可以实现药物的即时释放。
