Volokhova Apollinariya A, Fedorishin Dmitry A, Khvastunova Arina O, Spiridonova Tatiana I, Kozelskaya Anna I, Kzhyshkowska Julia, Tverdokhlebov Sergei I, Kurzina Irina
Department of Translational Cellular and Molecular Biomedicine, Chemical Faculty, National Research Tomsk State University, 36 Lenin Avenue, 634050 Tomsk, Russia.
The Weinberg Research Center, National Research Tomsk Polytechnic University, 30 Lenin Avenue, 634050 Tomsk, Russia.
Polymers (Basel). 2022 Jan 18;14(3):373. doi: 10.3390/polym14030373.
Surface modification with the plasma of the direct current reactive magnetron sputtering has demonstrated its efficacy as a tool for enhancing the biocompatibility of polymeric electrospun scaffolds. Improvement of the surface wettability of materials with water, as well as the formation of active chemical bonds in the near-surface layers, are the main reasons for the described effect. These surface effects are also known to increase the release rate of drugs incorporated in fibers. Herein, we investigated the effect of plasma modification on the chloramphenicol release from electrospun poly (lactic acid) fibrous scaffolds. Scaffolds with high-50 wt./wt.%-drug content were obtained. It was shown that plasma modification leads to an increase in the drug release rate and drug diffusion coefficient, while not deteriorating surface morphology and mechanical properties of scaffolds. The materials' antibacterial activity was observed to increase in the first day of the experiment, while remaining on the same level as the unmodified group during the next six days. The proposed technique for modifying the surface of scaffolds will be useful for obtaining drug delivery systems with controlled accelerated release, which can expand the possibilities of local applications of antibiotics and other drugs.
直流反应磁控溅射等离子体表面改性已证明其作为增强聚合物电纺支架生物相容性工具的有效性。材料表面亲水性的改善以及近表面层中活性化学键的形成是上述效果的主要原因。这些表面效应还已知会增加纤维中所含药物的释放速率。在此，我们研究了等离子体改性对电纺聚乳酸纤维支架中氯霉素释放的影响。获得了药物含量高达50 wt./wt.%的支架。结果表明，等离子体改性导致药物释放速率和药物扩散系数增加，同时不会恶化支架的表面形态和力学性能。在实验的第一天观察到材料的抗菌活性增加，而在接下来的六天中与未改性组保持在同一水平。所提出的支架表面改性技术将有助于获得具有可控加速释放的药物递送系统，这可以扩大抗生素和其他药物局部应用的可能性。
