CpG 密度是否是表观遗传衰老与寿命之间的联系？
Is CpG Density the Link between Epigenetic Aging and Lifespan?
机构信息
Savannah River Ecology Laboratory, Aiken, SC 29802, USA; Eugene P. Odum School of Ecology, University of Georgia, Athens, GA 30602, USA.
Savannah River Ecology Laboratory, Aiken, SC 29802, USA; Eugene P. Odum School of Ecology, University of Georgia, Athens, GA 30602, USA.
出版信息
Trends Genet. 2020 Oct;36(10):725-727. doi: 10.1016/j.tig.2020.06.003. Epub 2020 Jul 2.
The genetic mechanisms contributing to lifespan variation remain unresolved. Based on recent conceptual advances in our understanding of epigenetic potential and the relocalization of chromatin modifiers (RCM), we hypothesize that increased CpG density is protective against age-related erosion of the epigenetic landscape and may explain interspecific variation in lifespan.
导致寿命变化的遗传机制仍未得到解决。基于我们最近在理解表观遗传潜力和染色质修饰剂重定位（RCM）方面的概念性进展，我们假设增加 CpG 密度可以防止与年龄相关的表观遗传景观的侵蚀，并可能解释寿命的种间变异。
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