Myers J B, Frost M, Coates A S, Mathews J D, Kincaid-Smith P
Aust N Z J Med. 1977 Feb;7(1):16-9. doi: 10.1111/j.1445-5994.1977.tb03349.x.
Carcinoembryonic antigen (CEA) was estimated in plasma from 70 patients with a renal transplant, 105 patients with glomerulonephritis who had received immunosuppressive therapy, and 124 healthy controls. There were raised levels in 30% of those with a renal transplant, 10% of those with glomerulonephritis and 2% of controls, and levels were higher in current smokers. CEA levels did not correlate with pre-transplant dialysis time nor with serum creatinine levels, but tended to fall with increasing time after transplantation, especially in non-smokers. CEA levels did not correlate with prednisolone dosage nor with number of rejection episodes, after allowing for time after transplantation and smoking habit. Nine of 70 patients with a renal transplant and three of 105 with glomerulonephritis had cancer, of skin in seven, cervix uteri in four, and colon in one. CEA was raised in all four transplant recipients with a visceral cancer (cervix three and colon one), but in none of the five with cutaneous cancer. Raised CEA levels occurring late after a renal allograft should prompt a careful search for visceral cancer.
对70例肾移植患者、105例接受免疫抑制治疗的肾小球肾炎患者以及124名健康对照者的血浆癌胚抗原（CEA）进行了测定。肾移植患者中有30%、肾小球肾炎患者中有10%以及对照者中有2%的CEA水平升高，且当前吸烟者的CEA水平更高。CEA水平与移植前透析时间及血清肌酐水平均无相关性，但随着移植后时间的延长有下降趋势，尤其是在不吸烟者中。在考虑移植后时间和吸烟习惯后，CEA水平与泼尼松龙剂量及排斥反应次数均无相关性。70例肾移植患者中有9例、105例肾小球肾炎患者中有3例患有癌症，其中7例为皮肤癌，4例为宫颈癌，1例为结肠癌。所有4例患有内脏癌（3例宫颈癌和1例结肠癌）的移植受者的CEA水平均升高，但5例皮肤癌患者的CEA水平均未升高。肾移植后晚期出现的CEA水平升高应促使仔细筛查内脏癌。
