Rychen Guido, Aquilina Gabriele, Azimonti Giovanna, Bampidis Vasileios, Bastos Maria de Lourdes, Bories Georges, Chesson Andrew, Cocconcelli Pier Sandro, Flachowsky Gerhard, Gropp Jürgen, Kolar Boris, Kouba Maryline, López-Alonso Marta, López Puente Secundino, Mayo Baltasar, Ramos Fernando, Saarela Maria, Villa Roberto Edoardo, Wallace Robert John, Wester Pieter, Pechova Alena, López-Gálvez Gloria, Mantovani Alberto
EFSA J. 2018 Mar 8;16(3):e05197. doi: 10.2903/j.efsa.2018.5197. eCollection 2018 Mar.
The additive, 'Zinc-l-selenomethionine' (Zn-l-SeMet) is intended to be used as a source of selenium for all animal species. The applicant intends to market the active compound blended with inert carriers (AvailaSe). Zn-l-SeMet is a safe source of selenium for chickens for fattening; the conclusion is extended to all animal species. Selenium from Zn-l-SeMet does not elicit any adverse effects not expected for a selenium compound. The use of Zn-l-SeMet in animal nutrition is expected to result in a similar increase in selenium deposition in animal tissues/products as that resulting from other sources of SeMet. The use of the additive up to the maximum selenium supplementation level established for other sources of organic selenium (0.2 mg/kg complete feed) and complying with the maximum authorised total selenium content is safe for consumers. The additive is hazardous upon inhalation; owing to the high dusting potential, persons handling AvailaSe are at risk by inhalation. AvailaSe is not an irritant to the skin. In the absence of data, no conclusion on the eye irritation and skin sensitisation can be drawn. The use of Zn-l-SeMet in feed does not pose an additional risk to the environment, compared with other sources of selenium for which it will substitute, as long as the maximum authorised content in complete feed is not exceeded. Zn-l-SeMet is an effective source of selenium in chickens for fattening and laying hens; this conclusion is extended to all animal species. The maximum contribution of zinc in total feed deriving from the use of the additive (< 0.2 mg Zn/kg feed) is considered low and does not need any safety assessment except for users.
添加剂“L-硒代蛋氨酸锌”(Zn-L-SeMet)拟用作所有动物物种的硒源。申请人打算将活性化合物与惰性载体混合后进行销售(商品名AvailaSe)。Zn-L-SeMet是育肥鸡安全的硒源;该结论适用于所有动物物种。Zn-L-SeMet中的硒不会引发硒化合物未预期的任何不良影响。预计在动物营养中使用Zn-L-SeMet会使动物组织/产品中的硒沉积量增加,与其他蛋氨酸硒源产生的增加量相似。在按照为其他有机硒源确定的最大硒添加水平(0.2毫克/千克全价饲料)使用该添加剂且符合总硒最大允许含量的情况下,对消费者是安全的。该添加剂吸入有害;由于扬尘可能性高,处理AvailaSe的人员有吸入风险。AvailaSe对皮肤无刺激性。在缺乏数据的情况下,无法得出关于眼刺激性和皮肤致敏性的结论。与它所替代的其他硒源相比,只要不超过全价饲料中的最大允许含量,在饲料中使用Zn-L-SeMet不会对环境造成额外风险。Zn-L-SeMet是育肥鸡和产蛋母鸡有效的硒源;该结论适用于所有动物物种。使用该添加剂导致的锌在总饲料中的最大贡献量(<0.2毫克锌/千克饲料)被认为较低,除使用者外无需进行任何安全性评估。