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基于帝斯曼营养产品国际有限公司提交的一份档案,钼化合物(E7)二水合钼酸钠作为绵羊饲料添加剂的安全性和有效性

Safety and efficacy of a molybdenum compound (E7) sodium molybdate dihydrate as feed additive for sheep based on a dossier submitted by Trouw Nutrition International B.V.

作者信息

Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Dusemund Birgit, Kouba Maryline, Kos Durjava Mojca, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Ramos Fernando, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Flachowsky Gerhard, Gropp Jürgen, Cubadda Francesco, López-Gálvez Gloria, Mantovani Alberto

出版信息

EFSA J. 2019 Feb 27;17(2):e05606. doi: 10.2903/j.efsa.2019.5606. eCollection 2019 Feb.

Abstract

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on safety and efficacy of sodium molybdate dihydrate for sheep, based on a dossier submitted for the re-evaluation of the additive. The additive is currently authorised in the EU for all animal species as 'Nutritional additive' - 'Compounds of trace elements'. Taking the optimal Cu:Mo ratio of 3-10, and the highest total copper level authorised in complete feeds for sheep (15 mg/kg), the FEEDAP Panel concluded that 2.5 mg total Mo/kg complete feed is safe for sheep. Considering (i) a safe intake of 0.6 mg Mo/day, (ii) the estimate average intake figure from food in Europe (generally less than 100 μg/day), (iii) the contribution of foods of animal origin to the total molybdenum intake (estimated to be up to 22 %), and (iv) that molybdenum would not accumulate in edible tissues/products of sheep fed molybdenum supplemented diets up to the upper safe level, the FEEDAP Panel concluded that the use of sodium molybdate as a additive in sheep at 2.5 mg total Mo/kg complete feed is safe for consumers. The additive under assessment feed poses no risk by inhalation to users; it is a skin and eye irritant, but it is not considered as a skin sensitiser. Sodium molybdate used up to 2.5 mg Mo/kg complete sheep feed poses no concerns for the safety for the environment. The FEEDAP Panel recognises that molybdenum does not need to be added to diets to cover the nutritional needs of molybdenum of sheep. Molybdenum supplementation in sheep feed is considered effective in order to guarantee an adequate balance with copper, when the Cu:Mo ratio in the diet is in the range 3-10.

摘要

应欧盟委员会的要求,动物饲料添加剂及产品或物质专家小组(FEEDAP)被要求根据提交的添加剂重新评估档案,就二水钼酸钠对绵羊的安全性和有效性发表科学意见。该添加剂目前在欧盟被批准作为“营养添加剂”——“微量元素化合物”用于所有动物物种。考虑到铜与钼的最佳比例为3至10,以及绵羊全价饲料中批准的最高总铜水平(15毫克/千克),FEEDAP专家小组得出结论,全价饲料中总钼含量为2.5毫克/千克对绵羊是安全的。考虑到:(i)钼的安全摄入量为0.6毫克/天,(ii)欧洲食物中的估计平均摄入量(通常低于100微克/天),(iii)动物源性食物对总钼摄入量的贡献(估计高达22%),以及(iv)在补充钼的日粮中,绵羊的可食用组织/产品中的钼不会积累到安全上限水平,FEEDAP专家小组得出结论,在绵羊饲料中使用总钼含量为2.5毫克/千克的钼酸钠作为添加剂对消费者是安全的。所评估的添加剂饲料对使用者不会造成吸入风险;它是皮肤和眼睛刺激物,但不被视为皮肤致敏剂。在绵羊全价饲料中使用高达2.5毫克钼/千克的钼酸钠对环境安全没有影响。FEEDAP专家小组认识到,不需要在日粮中添加钼来满足绵羊对钼的营养需求。当日粮中铜与钼的比例在3至10范围内时,在绵羊饲料中补充钼被认为是有效的,以保证与铜有足够的平衡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36b1/7009221/5d5c875c999d/EFS2-17-e05606-g004.jpg

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