来自HLA - A2转基因小鼠的细胞毒性T淋巴细胞，对人类细胞上表达的HLA - A2具有特异性。
Cytotoxic T lymphocytes from HLA-A2 transgenic mice specific for HLA-A2 expressed on human cells.
作者信息
Bernhard E J, Le A X, Barbosa J A, Lacy E, Engelhard V H
机构信息
Department of Microbiology, University of Virginia, Charlottesville 22908.
出版信息
J Exp Med. 1988 Sep 1;168(3):1157-62. doi: 10.1084/jem.168.3.1157.
Abstract
CTL clones were derived from HLA-A2.1 transgenic mice by immunization with a human cell expressing HLA-A2.1. None of these clones lysed murine transfectants, and only 3 of 23 lysed monkey transfectants expressing HLA-A2. In contrast, all of these clones lysed a wide variety of human cells expressing HLA-A2.1. These results demonstrate the existence of species-specific epitopes on the HLA-A2.1 molecule, and suggest that these epitopes are formed by the association of class I MHC products with one or more endogenous species-specific molecules. These results provide an explanation for the frequently observed failure of HLA class I-specific CTL to recognize these antigens on murine transfectants. These results also suggest that such endogenous proteins may also contribute to the formation of epitopes recognized by allospecific CTL.
摘要
通过用表达HLA - A2.1的人细胞免疫，从HLA - A2.1转基因小鼠中获得细胞毒性T淋巴细胞（CTL）克隆。这些克隆均未裂解鼠转染细胞，23个克隆中只有3个裂解了表达HLA - A2的猴转染细胞。相比之下，所有这些克隆都能裂解多种表达HLA - A2.1的人细胞。这些结果证明了HLA - A2.1分子上存在物种特异性表位，并表明这些表位是由I类主要组织相容性复合体（MHC）产物与一种或多种内源性物种特异性分子结合形成的。这些结果解释了经常观察到的HLA I类特异性CTL无法识别鼠转染细胞上这些抗原的现象。这些结果还表明，此类内源性蛋白质也可能有助于同种特异性CTL识别的表位的形成。
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