Sun Yu, Yang Yu-Han, Wang Jun, Jiang Hai-Qiang, Cui Ning, Su Ben-Zheng, Yu Zong-Yuan
College of Pharmacy, Shandong University of Traditional Chinese Medicine Ji'nan 250335, China.
Shandong Institute of Traditional Chinese Medicine Ji'nan 250014, China.
Zhongguo Zhong Yao Za Zhi. 2020 Jun;45(12):2784-2791. doi: 10.19540/j.cnki.cjcmm.20200328.201.
Jiaotai Pills is a traditional medical prescription to treat the incompatibility of heart and kidney. It has the distinctive functions of heart and kidney communication, sedation and hypnosis, anti-anxiety and depression, as well as the improvement of insulin resistance. However, this pill is broadly used to cure insomnia, anxiety, depression, and diabetes in the contemporary clinical trials. Based on the article, it illustrates the research progress of the chemical ingredients, pharmacological actions, and clinical applications of Jiaotai Pills. With respect to the "five principles" of Q-marker in Chinese medicine, the Q-marker of Jiaotai Pills is comprehensively predicted and analyzed, noting that berberine, epiberberine, coptisine chloride, palmatine chloride, berberine chloride, berberrubine chloride, ferulic acid, cinnamic acid, cinnamaldehyde, proanthocyanidin B2 can be treated as the Q-marker of Jiaotai Pills. In addition, these components of Q-marker have been selected as indicators to provide a significant reference for the quality control and surveillance research of Jiaotai Pills.
交泰丸是治疗心肾不交的传统中药方剂。它具有独特的心肾交通、镇静催眠、抗焦虑和抑郁以及改善胰岛素抵抗的功能。然而，在当代临床试验中，该药丸被广泛用于治疗失眠、焦虑、抑郁和糖尿病。基于这篇文章，阐述了交泰丸的化学成分、药理作用及临床应用的研究进展。依据中药Q-标志物的“五原则”，对交泰丸的Q-标志物进行了全面预测与分析，指出小檗碱、表小檗碱、盐酸黄连碱、盐酸巴马汀、氯化小檗碱、氯化berberrubine、阿魏酸、肉桂酸、肉桂醛、原花青素B2可作为交泰丸的Q-标志物。此外，这些Q-标志物成分已被选为指标，为交泰丸的质量控制和监测研究提供重要参考。
