Marine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway (NUI Galway), University Road, H91 TK33 Galway, Ireland.
Departamento de Farmacología, Facultad de Veterinaria, Universidade de Santiago de Compostela, 27002 Lugo, Spain.
J Nat Prod. 2020 Jul 24;83(7):2299-2304. doi: 10.1021/acs.jnatprod.0c00223. Epub 2020 Jul 6.
The chemical investigation of the sponge aff. collected around Futuna Islands in the Pacific Ocean led to the isolation of three new dimeric pyrrole 2-aminoimidazole alkaloids (PIAs). Futunamine () features an unprecedented pyrrolo[1,2-]imidazole core, while two other new dimeric PIAs were identified as analogues of palau'amine. Together with other known PIAs isolated from this species, they were shown to exhibit anti-inflammatory and neuroprotective activities.
对在太平洋富图纳群岛周围采集的 属海绵的化学成分研究导致了三种新的二聚吡咯 2-氨基咪唑生物碱（PIA）的分离。富田胺（ ）具有前所未有的吡咯并[1,2-]咪唑核心，而另外两种新的二聚 PIA 则被鉴定为 palau'amine 的类似物。与从该物种中分离出的其他已知 PIA 一起，它们表现出抗炎和神经保护活性。
