Where there's smoke, there's fire: Cannabis, P2RX7 and inflammatory pathways intersect to increase psychosis susceptibility.
作者信息
Goldsmith David R
机构信息
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta GA, USA.
出版信息
Brain Behav Immun. 2020 Oct;89:3-4. doi: 10.1016/j.bbi.2020.06.031. Epub 2020 Jul 3.
Abstract
摘要
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Where there's smoke, there's fire: Cannabis, P2RX7 and inflammatory pathways intersect to increase psychosis susceptibility.无风不起浪：大麻、P2RX7与炎症通路相互作用增加精神病易感性。
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本文引用的文献
1
Cannabinoids and psychotic symptoms: A potential role for a genetic variant in the P2X purinoceptor 7 (P2RX7) gene.大麻素与精神病症状：P2X 嘌呤能受体 7（P2RX7）基因中的遗传变异可能起作用。
Brain Behav Immun. 2020 Aug;88:573-581. doi: 10.1016/j.bbi.2020.04.051. Epub 2020 Apr 21.
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Can anti-inflammatory strategies light up the dim depression pipeline?抗炎策略能否照亮黯淡的抑郁症治疗前景？
Nat Rev Drug Discov. 2020 Apr;19(4):224-225. doi: 10.1038/d41573-020-00049-5.
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Psychiatric symptoms caused by cannabis constituents: a systematic review and meta-analysis.大麻成分引起的精神症状：系统评价与荟萃分析。
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The microglial ATP-gated ion channel P2X7 as a CNS drug target.作为中枢神经系统药物靶点的小胶质细胞ATP门控离子通道P2X7
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