Hsu Chuan-Chih, Cheng Yu-Wei, Liu Che-Chun, Peng Xin-Yao, Yung Ming-Chi, Liu Ting-Yu
Division of Cardiovascular Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei Heart Institute, Taipei Medical University, Taipei 11031, Taiwan.
Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan.
Polymers (Basel). 2020 Jun 30;12(7):1467. doi: 10.3390/polym12071467.
We have successfully fabricated poly(3,4-ethylenedioxythiophene) (PEDOT) derivative nanohybrid coatings on flexible SUS316L stainless steel by electrochemical polymerization, which can offer anti-fouling and anti-bacterial capabilities. PEDOT derivative nanohybrids were prepared from polystyrene sulfonates (PSS) and graphene oxide (GO) incorporated into a conducting polymer of PEDOT. Additionally, the negative charge of the PEDOT/GO substrate was further modified by poly-diallyldimethylammonium chloride (PDDA) to form a positively charged surface. These PEDOT derivative nanohybrid coatings could provide a straightforward means of controlling the surface energy, roughness, and charges with the addition of various derivatives in the electrochemical polymerization and electrostatically absorbed process. The characteristics of the PEDOT derivative nanohybrid coatings were evaluated by Raman spectroscopy, scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), water contact angle, and surface potential (zeta potential). The results show that PEDOT/PSS and PEDOT/GO nanohybrid coatings exhibit excellent anti-fouling capability. Only 0.1% of bacteria can be adhered on the surface due to the lower surface roughness and negative charge surface by PEDOT/PSS and PEDOT/GO modification. Furthermore, the anti-bacterial capability (7 mm of inhibition zone) was observed after adding PDDA on the PEDOT/GO substrates, suggesting that the positive charge of the PEDOT/GO/PDDA substrate can effectively kill bacteria (). Given their anti-fouling and anti-bacterial capabilities, PEDOT derivative nanohybrid coatings have the potential to be applied to biomedical devices such as cardiovascular stents and surgical apparatus.
我们通过电化学聚合成功地在柔性SUS316L不锈钢上制备了聚（3,4-乙撑二氧噻吩）（PEDOT）衍生物纳米杂化涂层，该涂层具有防污和抗菌能力。PEDOT衍生物纳米杂化物由聚苯乙烯磺酸盐（PSS）和氧化石墨烯（GO）掺入PEDOT导电聚合物中制备而成。此外，PEDOT/GO基底的负电荷通过聚二烯丙基二甲基氯化铵（PDDA）进一步改性，以形成带正电的表面。这些PEDOT衍生物纳米杂化涂层可以通过在电化学聚合和静电吸附过程中添加各种衍生物，提供一种直接控制表面能、粗糙度和电荷的方法。通过拉曼光谱、扫描电子显微镜（SEM）、X射线光电子能谱（XPS）、原子力显微镜（AFM）、水接触角和表面电位（zeta电位）对PEDOT衍生物纳米杂化涂层的特性进行了评估。结果表明，PEDOT/PSS和PEDOT/GO纳米杂化涂层具有优异的防污能力。由于PEDOT/PSS和PEDOT/GO改性导致表面粗糙度较低且表面带负电荷，只有0.1%的细菌能够附着在表面。此外，在PEDOT/GO基底上添加PDDA后观察到抗菌能力（抑菌圈为7毫米），这表明PEDOT/GO/PDDA基底的正电荷能够有效杀灭细菌。鉴于其防污和抗菌能力，PEDOT衍生物纳米杂化涂层有潜力应用于生物医学设备，如心血管支架和手术器械。
