吲哚洛尔局部及全身应用对眼和心血管的影响。
Ocular and cardiovascular effects of local and systemic pindolol.
作者信息
Smith S E, Smith S A, Reynolds F, Whitmarsh V B
出版信息
Br J Ophthalmol. 1979 Jan;63(1):63-6. doi: 10.1136/bjo.63.1.63.
Abstract
Ocular and cardiovascular effects of topical and intravenous pindolol have been studied in a balanced cross-0ver double-blind trial in 6 healthy volunteers. When applied to 1 eye pindolol lowered intraocular pressure in both the treated and untreated eyes with only minimal reduction in resting pupil diameter and light reflex response. The concentration in plasma was much lower and inhibiton of exercise tachycardia about half that when the same dose was administered intravenously. The findings suggest that beta-adrenoceptor blocking drugs should not be used in the treatment of glaucoma in patients who also suffer from heart failure.
摘要
在一项针对6名健康志愿者的平衡交叉双盲试验中，研究了局部和静脉注射吲哚洛尔对眼部和心血管的影响。当将吲哚洛尔应用于一只眼睛时，治疗眼和未治疗眼的眼压均降低，静息瞳孔直径和光反射反应仅略有降低。血浆中的浓度要低得多，对运动性心动过速的抑制作用约为静脉注射相同剂量时的一半。这些发现表明，β-肾上腺素受体阻断药物不应用于同时患有心力衰竭的青光眼患者的治疗。
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