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升华自旋冻结溶液的原位X射线成像

In-Situ X-ray Imaging Of Sublimating Spin-Frozen Solutions.

作者信息

Goethals Wannes, Vanbillemont Brecht, Lammens Joris, De Beer Thomas, Vervaet Chris, Boone Matthieu N

机构信息

Department of Physics and Astronomy, Radiation Physics, Ghent University, Proeftuinstraat 86/N12, B-9000 Gent, Belgium.

Centre for X-ray Tomography (UGCT), Ghent University, Proeftuinstraat 86, B-9000 Gent, Belgium.

出版信息

Materials (Basel). 2020 Jul 1;13(13):2953. doi: 10.3390/ma13132953.

DOI:10.3390/ma13132953
PMID:32630310
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7378758/
Abstract

Spin-freeze-drying is a promising technique to enable long-term storage of pharmaceutical unit doses of aqueous drug solutions. To investigate the sublimation of the ice during the primary phase of freeze-drying, X-ray imaging can yield crucial temporally resolved information on the local dynamics. In this paper, we describe a methodology to investigate the sublimation front during single unit-dose freeze-drying using 4D in-situ X-ray imaging. Three spin-frozen samples of different solutions were imaged using this methodology and the process characteristics were analysed and reduced to two-dimensional feature maps.

摘要

旋转冷冻干燥是一种很有前景的技术，可实现水性药物溶液药物单位剂量的长期储存。为了研究冷冻干燥初级阶段冰的升华情况，X射线成像可以提供有关局部动力学的关键时间分辨信息。在本文中，我们描述了一种使用4D原位X射线成像研究单单位剂量冷冻干燥过程中升华前沿的方法。使用该方法对三种不同溶液的旋转冷冻样品进行成像，并分析过程特征并将其简化为二维特征图。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/40c841292f65/materials-13-02953-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/081868500565/materials-13-02953-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/e90a4305e892/materials-13-02953-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/c74bda8d6188/materials-13-02953-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/e809c05e216c/materials-13-02953-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/c715d88e1b6f/materials-13-02953-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/40c841292f65/materials-13-02953-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/081868500565/materials-13-02953-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/9c45382c0f39/materials-13-02953-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/f4ce034be1a2/materials-13-02953-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/e90a4305e892/materials-13-02953-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/e60bcc6a597c/materials-13-02953-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/3701ca84a26a/materials-13-02953-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/0ec4c84fbad1/materials-13-02953-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/c74bda8d6188/materials-13-02953-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/e809c05e216c/materials-13-02953-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/c715d88e1b6f/materials-13-02953-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27d/7378758/40c841292f65/materials-13-02953-g011.jpg

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本文引用的文献

1
4D Micro-Computed X-ray Tomography as a Tool to Determine Critical Process and Product Information of Spin Freeze-Dried Unit Doses.4D 微计算机 X 射线断层扫描作为确定自旋冻干单位剂量关键工艺和产品信息的工具。
Pharmaceutics. 2020 May 7;12(5):430. doi: 10.3390/pharmaceutics12050430.
2
Innovations in laboratory-based dynamic micro-CT to accelerate in situ research.基于实验室的动态 micro-CT 的创新，以加速原位研究。
J Microsc. 2020 Mar;277(3):197-209. doi: 10.1111/jmi.12879. Epub 2020 Mar 3.
3
Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations.
积极进取！无定形辅料助力单克隆抗体制剂一步冻干
Pharmaceutics. 2019 Nov 17;11(11):616. doi: 10.3390/pharmaceutics11110616.
4
Using X-ray tomoscopy to explore the dynamics of foaming metal.使用X射线断层扫描技术探究泡沫金属的动力学特性。
Nat Commun. 2019 Aug 21;10(1):3762. doi: 10.1038/s41467-019-11521-1.
5
Ab initio nonrigid X-ray nanotomography.从头开始的非刚性 X 射线纳米断层摄影术。
Nat Commun. 2019 Jun 13;10(1):2600. doi: 10.1038/s41467-019-10670-7.
6
Discrepancy between thermodynamic and kinetic stabilities of the tert-butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying.叔丁醇水合物的热力学和动力学稳定性之间的差异及其对通过冷冻干燥获得药用粉末的影响。
Chem Commun (Camb). 2019 Apr 4;55(29):4262-4265. doi: 10.1039/c9cc00397e.
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Thermal Imaging as a Noncontact Inline Process Analytical Tool for Product Temperature Monitoring during Continuous Freeze-Drying of Unit Doses.热成像作为一种非接触式在线过程分析工具，用于连续冻干单剂量产品过程中的产品温度监测。
Anal Chem. 2018 Nov 20;90(22):13591-13599. doi: 10.1021/acs.analchem.8b03788. Epub 2018 Oct 30.
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In-Situ High Resolution Dynamic X-ray Microtomographic Imaging of Olive Oil Removal in Kitchen Sponges by Squeezing and Rinsing.通过挤压和冲洗对厨房海绵中橄榄油去除过程进行原位高分辨率动态X射线显微断层成像
Materials (Basel). 2018 Aug 20;11(8):1482. doi: 10.3390/ma11081482.
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Imaging Techniques to Characterize Cake Appearance of Freeze-Dried Products.用于描述冻干产品表面形态的成像技术。
J Pharm Sci. 2018 Nov;107(11):2810-2822. doi: 10.1016/j.xphs.2018.06.025. Epub 2018 Jul 10.
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Motion compensated micro-CT reconstruction for in-situ analysis of dynamic processes.用于动态过程原位分析的运动补偿微型计算机断层扫描重建
Sci Rep. 2018 May 16;8(1):7655. doi: 10.1038/s41598-018-25916-5.