Mostafa Ahmed, Kandeil Ahmed, Shehata Mahmoud, El Shesheny Rabeh, Samy Abdallah M, Kayali Ghazi, Ali Mohamed A
Center of Scientific Excellence for Influenza Viruses, Environmental Research Division, National Research Centre (NRC), Cairo 12622, Egypt.
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Microorganisms. 2020 Jul 2;8(7):991. doi: 10.3390/microorganisms8070991.
Coronaviruses belong to a large family of viruses that can cause disease outbreaks ranging from the common cold to acute respiratory syndrome. Since 2003, three zoonotic members of this family evolved to cross species barriers infecting humans and resulting in relatively high case fatality rates (CFR). Compared to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV, CFR = 10%) and pandemic Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, CFR = 6%), the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has scored the highest CFR (approximately 35%). In this review, we systematically summarize the current state of scientific knowledge about MERS-CoV, including virology and origin, epidemiology, zoonotic mode of transmission, and potential therapeutic or prophylactic intervention modalities.
冠状病毒属于一个庞大的病毒家族，可引发从普通感冒到急性呼吸综合征等一系列疾病爆发。自2003年以来，该家族的三种人畜共患病毒成员进化后跨越物种屏障感染人类，并导致相对较高的病死率（CFR）。与严重急性呼吸综合征冠状病毒（SARS-CoV，病死率=10%）和大流行的严重急性呼吸综合征冠状病毒2（SARS-CoV-2，病死率=6%）相比，中东呼吸综合征冠状病毒（MERS-CoV）的病死率最高（约35%）。在本综述中，我们系统地总结了关于MERS-CoV的科学知识现状，包括病毒学和起源、流行病学、人畜共患传播模式以及潜在的治疗或预防干预方式。
