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源自小鼠基底神经节的文献衍生细胞测量数据库。

Database of literature derived cellular measurements from the murine basal ganglia.

机构信息

Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

出版信息

Sci Data. 2020 Jul 6;7(1):211. doi: 10.1038/s41597-020-0550-3.

Abstract

Quantitative measurements and descriptive statistics of different cellular elements in the brain are typically published in journal articles as text, tables, and example figures, and represent an important basis for the creation of biologically constrained computational models, design of intervention studies, and comparison of subject groups. Such data can be challenging to extract from publications and difficult to normalise and compare across studies, and few studies have so far attempted to integrate quantitative information available in journal articles. We here present a database of quantitative information about cellular parameters in the frequently studied murine basal ganglia. The database holds a curated and normalised selection of currently available data collected from the literature and public repositories, providing the most comprehensive collection of quantitative neuroanatomical data from the basal ganglia to date. The database is shared as a downloadable resource from the EBRAINS Knowledge Graph (https://kg.ebrains.eu), together with a workflow that allows interested researchers to update and expand the database with data from future reports.

摘要

大脑中不同细胞成分的定量测量和描述性统计数据通常以文本、表格和示例图的形式发表在期刊文章中,是创建受生物学约束的计算模型、干预研究设计和比较研究对象的重要基础。从出版物中提取此类数据具有挑战性,并且难以在研究之间进行标准化和比较,到目前为止,很少有研究试图整合期刊文章中提供的定量信息。我们在这里提供了一个关于经常研究的鼠基底神经节中细胞参数的定量信息数据库。该数据库包含从文献和公共存储库中收集的经过精心整理和标准化的现有数据选择,提供了迄今为止来自基底神经节的最全面的定量神经解剖学数据集合。该数据库作为可下载资源与 EBRAINS 知识图谱(https://kg.ebrains.eu)共享,并提供了一个工作流程,允许有兴趣的研究人员使用未来报告中的数据更新和扩展数据库。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5b4/7338524/4e3cff552558/41597_2020_550_Fig1_HTML.jpg

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