结节病中CD4阳性T细胞亚群的分析。
Analysis of CD4-positive T cell subpopulation in sarcoidosis.
作者信息
Gerli R, Darwish S, Broccucci L, Minotti V, Spinozzi F, Cernetti C, Bertotto A, Rambotti P
机构信息
Istituti di Clinica Medica I, University of Perugia, Italy.
出版信息
Clin Exp Immunol. 1988 Aug;73(2):226-9.
Abstract
Double-labelling immunofluorescence analysis within the CD4+ cell subset was carried out in 27 bronchoalveolar lavage fluids and 11 peripheral blood samples of sarcoidosis patients with anti-TQ1, anti-2H4 and anti-4B4 monoclonal antibodies. Helper/inducer CD4+TQ1-/4B4+ cells were strongly increased in the lung and slightly, but significantly, decreased in the blood of sarcoidosis patients with respect to normal controls. No differences were found in the number of both lung and blood CD4+2H4+ cells between sarcoidosis patients and controls. The findings are further evidence for a compartmentalization of T cell subsets in sarcoidosis.
摘要
使用抗TQ1、抗2H4和抗4B4单克隆抗体，对27例结节病患者的支气管肺泡灌洗液和11份外周血样本进行了CD4 +细胞亚群内的双标免疫荧光分析。与正常对照相比，结节病患者肺部辅助/诱导性CD4 + TQ1 - / 4B4 +细胞显著增加，而血液中该细胞略有减少但差异显著。结节病患者与对照组之间，肺部和血液中CD4 + 2H4 +细胞数量均未发现差异。这些发现进一步证明了结节病中T细胞亚群的分隔现象。
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本文引用的文献
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Bronchoalveolar lavage.支气管肺泡灌洗
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Alveolar lymphocyte activation during sarcoidosis.结节病期间的肺泡淋巴细胞活化。
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