Pan Daniel, Sze Shirley, Minhas Jatinder S, Bangash Mansoor N, Pareek Nilesh, Divall Pip, Williams Caroline Ml, Oggioni Marco R, Squire Iain B, Nellums Laura B, Hanif Wasim, Khunti Kamlesh, Pareek Manish
Department of Respiratory Sciences, University of Leicester, United Kingdom.
Department of Infection and HIV Medicine, Leicester Royal Infirmary, University Hospitals Leicester NHS Trust, United Kingdom.
EClinicalMedicine. 2020 Jun 3;23:100404. doi: 10.1016/j.eclinm.2020.100404. eCollection 2020 Jun.
The relationship between ethnicity and COVID-19 is uncertain. We performed a systematic review to assess whether ethnicity has been reported in patients with COVID-19 and its relation to clinical outcomes.
We searched EMBASE, MEDLINE, Cochrane Library and PROSPERO for English-language citations on ethnicity and COVID-19 (1 December 2019-15 May 2020). We also reviewed: COVID-19 articles in , clinical trial protocols, grey literature, surveillance data and preprint articles on COVID-19 in to evaluate if the association between ethnicity and clinical outcomes were reported and what they showed. PROSPERO:180654.
Of 207 articles in the database search, five reported ethnicity; two reported no association between ethnicity and mortality. Of 690 articles identified from medical journals, 12 reported ethnicity; three reported no association between ethnicity and mortality. Of 209 preprints, 34 reported ethnicity - 13 found Black, Asian and Minority Ethnic (BAME) individuals had an increased risk of infection with SARS-CoV-2 and 12 reported worse clinical outcomes, including ITU admission and mortality, in BAME patients compared to White patients. Of 12 grey literature reports, seven with original data reported poorer clinical outcomes in BAME groups compared to White groups.
Data on ethnicity in patients with COVID-19 in the published medical literature remains limited. However, emerging data from the grey literature and preprint articles suggest BAME individuals are at an increased risk of acquiring SARS-CoV-2 infection compared to White individuals and also worse clinical outcomes from COVID-19. Further work on the role of ethnicity in the current pandemic is of urgent public health importance.
NIHR.
种族与2019冠状病毒病（COVID-19）之间的关系尚不确定。我们进行了一项系统评价，以评估COVID-19患者中是否报告了种族情况及其与临床结局的关系。
我们在EMBASE、MEDLINE、Cochrane图书馆和PROSPERO中检索了关于种族与COVID-19的英文文献（2019年12月1日至2020年5月15日）。我们还查阅了：[具体数据库]中的COVID-19文章、临床试验方案、灰色文献、监测数据以及[具体数据库]中关于COVID-19的预印本文章，以评估种族与临床结局之间的关联是否有报告以及报告结果如何。PROSPERO注册号：180654。
在数据库检索出的207篇文章中，5篇报告了种族情况；2篇报告种族与死亡率之间无关联。从医学期刊中确定的690篇文章中，12篇报告了种族情况；3篇报告种族与死亡率之间无关联。在209篇预印本中，34篇报告了种族情况——13篇发现黑人、亚洲人和少数族裔（BAME）个体感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的风险增加，12篇报告与白人患者相比，BAME患者的临床结局更差，包括入住重症监护病房（ITU）和死亡率。在12篇灰色文献报告中，7篇有原始数据的报告显示，与白人组相比，BAME组的临床结局更差。
已发表医学文献中关于COVID-19患者种族情况的数据仍然有限。然而，灰色文献和预印本文章中的新数据表明，与白人个体相比，BAME个体感染SARS-CoV-2的风险增加，且COVID-19的临床结局更差。进一步研究种族在当前大流行中的作用具有紧迫的公共卫生重要性。
英国国家卫生研究院（NIHR）
