Levett P N
PHLS Anaerobe Reference Unit, Luton & Dunstable Hospital, UK.
J Antimicrob Chemother. 1988 Aug;22(2):167-73. doi: 10.1093/jac/22.2.167.
The susceptibility of 160 isolates of Clostridium difficile to eight antimicrobial agents was studied by two methods. There was generally good agreement between the results obtained with the disc diffusion and breakpoint methods. More than 90% of isolates studied were considered sensitive by both methods. However there was a major difference between the results obtained with the two methods for penicillin G and clindamycin, resistance to both agents being overestimated by the disc diffusion method. Several isolates exhibited multiple resistance to penicillin G, tetracycline, erythromycin and clindamycin. All isolates were inhibited by both metronidazole and vancomycin. None of the isolates produced beta-lactamase.
采用两种方法研究了160株艰难梭菌对8种抗菌药物的敏感性。纸片扩散法和断点法的结果总体上吻合良好。两种方法均认为超过90%的受试菌株敏感。然而，对于青霉素G和克林霉素，两种方法的结果存在重大差异，纸片扩散法高估了对这两种药物的耐药性。有几株菌株对青霉素G、四环素、红霉素和克林霉素表现出多重耐药性。所有菌株均被甲硝唑和万古霉素抑制。没有一株菌株产生β-内酰胺酶。
