来自抗生素相关性腹泻或结肠炎患者的艰难梭菌分离株的体外药敏性。
In vitro susceptibility of Clostridium difficile isolates from patients with antibiotic-associated diarrhea or colitis.
作者信息
Dzink J, Bartlett J G
出版信息
Antimicrob Agents Chemother. 1980 Apr;17(4):695-8. doi: 10.1128/AAC.17.4.695.
Abstract
In vitro susceptibility tests were performed on 84 strains of Clostridium difficile to 11 antimicrobial agents. All isolates were from the stools of patients with antibiotic-associated diarrhea or colitis in which there was a cytopathic toxin that was neutralized by Clostridium sordellii antitoxin. Over 95% of the strains were susceptible to vancomycin, penicillin G, ampicillin, and metronidazole at concentrations of 4 microgram/ml. Susceptibility to clindamycin was variable; 60% of the strains were susceptible at 1 microgram/ml, and 9% were resistant at 128 microgram/ml. Studies of individual isolates showed that a major portion of the strains were relatively susceptible to the antimicrobial agent implicated in causing the disease.
摘要
对84株艰难梭菌进行了11种抗菌药物的体外药敏试验。所有分离株均来自抗生素相关性腹泻或结肠炎患者的粪便，这些患者的粪便中存在一种被索氏梭菌抗毒素中和的细胞病变毒素。超过95%的菌株对浓度为4微克/毫升的万古霉素、青霉素G、氨苄西林和甲硝唑敏感。对克林霉素的敏感性存在差异；60%的菌株在1微克/毫升时敏感，9%的菌株在128微克/毫升时耐药。对单个分离株的研究表明，大部分菌株对与疾病发生有关的抗菌药物相对敏感。
相似文献
1
In vitro susceptibility of Clostridium difficile isolates from patients with antibiotic-associated diarrhea or colitis.
Antimicrob Agents Chemother. 1980 Apr;17(4):695-8. doi: 10.1128/AAC.17.4.695.
2
[Studies on Clostridium difficile and antimicrobial associated diarrhea or colitis].
Jpn J Antibiot. 1983 Feb;36(2):464-76.
3
In vitro susceptibility of Clostridium difficile isolates to 12 antimicrobial agents.
Chemioterapia. 1984 Feb;3(1):41-4.
4
Colitis induced by Clostridium difficile.
Rev Infect Dis. 1979 Mar-Apr;1(2):370-8. doi: 10.1093/clinids/1.2.370.
5
Role of Clostridium difficile in antibiotic-associated pseudomembranous colitis.
Gastroenterology. 1978 Nov;75(5):778-82.
6
Occurrence of toxin-producing Clostridium difficile in antibiotic-associated diarrhea in Sweden.
Med Microbiol Immunol. 1981;170(1):27-35. doi: 10.1007/BF02123794.
7
[Rate of isolation of "C. difficile" from stools of hospitalized patients: susceptibility of 75 strains (author's transl)].
Ann Microbiol (Paris). 1980 Jul-Aug;131B(1):11-20.
8
Experimental studies of antibiotic associated colitis.
Scand J Infect Dis Suppl. 1980(Suppl 22):11-5.
9
Medical management of antimicrobial-associated diarrhea and colitis.
Pharmacotherapy. 1982 Mar-Apr;2(2):100-9. doi: 10.1002/j.1875-9114.1982.tb03180.x.
10
Clostridium difficile: prevalence in horses and environment, and antimicrobial susceptibility.
Equine Vet J. 2003 Jul;35(5):465-71. doi: 10.2746/042516403775600505.
引用本文的文献
1
Penicillin Binding Protein Substitutions Cooccur with Fluoroquinolone Resistance in Epidemic Lineages of Multidrug-Resistant Clostridioides difficile.
mBio. 2023 Apr 25;14(2):e0024323. doi: 10.1128/mbio.00243-23. Epub 2023 Apr 5.
2
Antibiotic susceptibility of Clostridium difficile is similar worldwide over two decades despite widespread use of broad-spectrum antibiotics: an analysis done at the University Hospital of Zurich.
BMC Infect Dis. 2014 Nov 26;14:607. doi: 10.1186/s12879-014-0607-z.
3
Clostridium difficile isolates with increased sporulation: emergence of PCR ribotype 002 in Hong Kong.
Eur J Clin Microbiol Infect Dis. 2011 Nov;30(11):1371-81. doi: 10.1007/s10096-011-1231-0. Epub 2011 Apr 6.
4
A possible role for Clostridium difficile in the etiology of calf enteritis.
Vet Microbiol. 2008 Mar 18;127(3-4):343-52. doi: 10.1016/j.vetmic.2007.09.002. Epub 2007 Sep 18.
5
Antimicrobial susceptibilities and serogroups of clinical strains of Clostridium difficile isolated in France in 1991 and 1997.
Antimicrob Agents Chemother. 1999 Nov;43(11):2607-11. doi: 10.1128/AAC.43.11.2607.
6
Drug-induced Clostridium difficile-associated disease.
Drug Saf. 1997 Jul;17(1):37-46. doi: 10.2165/00002018-199717010-00003.
7
Occurrence of toxin-producing Clostridium difficile in antibiotic-associated diarrhea in Sweden.
Med Microbiol Immunol. 1981;170(1):27-35. doi: 10.1007/BF02123794.
8
Investigation of an outbreak of antibiotic-associated colitis by various typing methods.
J Clin Microbiol. 1982 Dec;16(6):1096-101. doi: 10.1128/jcm.16.6.1096-1101.1982.
9
Survey of the extrachromosomal gene pool of Clostridium difficile.
J Clin Microbiol. 1982 Oct;16(4):637-40. doi: 10.1128/jcm.16.4.637-640.1982.
10
Transferable resistance to clindamycin, erythromycin, and tetracycline in Clostridium difficile.
Antimicrob Agents Chemother. 1983 May;23(5):784-6. doi: 10.1128/AAC.23.5.784.
本文引用的文献
1
Clindamycin-associated colitis. Review of the clinical spectrum of 47 cases.
Am J Dig Dis. 1976 Jan;21(1):26-32. doi: 10.1007/BF01074135.
2
Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters.
J Infect Dis. 1977 Nov;136(5):701-5. doi: 10.1093/infdis/136.5.701.
3
Role of Clostridium difficile in antibiotic-associated pseudomembranous colitis.
Gastroenterology. 1978 Nov;75(5):778-82.
4
Identification of Clostridium difficile as a cause of pseudomembranous colitis.
Br Med J. 1978 Mar 18;1(6114):695. doi: 10.1136/bmj.1.6114.695.
5
Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia.
N Engl J Med. 1978 Mar 9;298(10):531-4. doi: 10.1056/NEJM197803092981003.
6
Antibiotic-associated colitis: effects of antibiotics on Clostridium difficile and the disease in hamsters.
Rev Infect Dis. 1979 Mar-Apr;1(2):386-97. doi: 10.1093/clinids/1.2.386.
7
Partial purification and characterization of a cytotoxin from Clostridium difficile.
Rev Infect Dis. 1979 Mar-Apr;1(2):379-85. doi: 10.1093/clinids/1.2.379.
8
Etiology of tetracycline-associated pseudomembranous colitis in hamsters.
Antimicrob Agents Chemother. 1979 Aug;16(2):167-70. doi: 10.1128/AAC.16.2.167.
9
Selective and differential medium for isolation of Clostridium difficile.
J Clin Microbiol. 1979 Feb;9(2):214-9. doi: 10.1128/jcm.9.2.214-219.1979.
10
Antibiotic-associated pseudomembranous colitis.
Rev Infect Dis. 1979 May-Jun;1(3):530-9. doi: 10.1093/clinids/1.3.530.
Zotero 插件