细胞器生物发生：内质网形态影响脂滴成核。

Organelle Biogenesis: ER Shape Influences Lipid Droplet Nucleation.

机构信息

Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

出版信息

Curr Biol. 2020 Jul 6;30(13):R770-R773. doi: 10.1016/j.cub.2020.05.027.

DOI:10.1016/j.cub.2020.05.027

PMID:32634419

Abstract

Lipid droplets (LDs) are neutral lipid storage organelles assembled at the endoplasmic reticulum (ER). A new study reveals that the high membrane curvature of ER tubules catalyzes the nucleation of a neutral lipid lens, an early step in LD biogenesis.

摘要

脂滴（LDs）是在内质网（ER）处组装的中性脂质储存细胞器。一项新的研究揭示，ER 小管的高膜曲率催化了中性脂质晶状体的成核，这是 LD 生物发生的早期步骤。