Centre for Nutrition, Department of Clinical Medicine, University of Bergen, 5021 Bergen, Norway.
Division of Gastroenterology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway.
Nutrients. 2020 Jul 4;12(7):1991. doi: 10.3390/nu12071991.
The risk of cardiovascular diseases and type 2 diabetes mellitus are increased in subjects with metabolic syndrome (MetS), and hydrolyzed fish protein may have favorable effects on metabolic health. Here, we investigated the effect of 8 weeks supplementation with 4 g of cod protein hydrolysate (CPH) on glucose metabolism, lipid profile and body composition in individuals with MetS in a double-blind, randomized intervention study with a parallel-group design. Subjects received a daily supplement of CPH ( = 15) or placebo ( = 15). Primary outcomes were serum fasting and postprandial glucose levels. Secondary outcomes were fasting and postprandial insulin and glucagon-like peptide 1 (GLP-1), fasting lipid concentrations and body composition. No difference was observed between CPH and placebo for insulin, glucose or GLP-1 after 8 weeks intervention. Fasting triacylglycerol decreased in both the CPH group and placebo group, with no change between groups. Fasting total cholesterol and low-density lipoprotein cholesterol decreased significantly within both groups from baseline to study end, but no difference was observed between the two groups. In conclusion, supplementing with a low dose of CPH in subjects with MetS for 8 weeks had no effect on fasting or postprandial levels of insulin, glucose or GLP-1, lipid profile or body composition.
患有代谢综合征（MetS）的受试者发生心血管疾病和 2 型糖尿病的风险增加，而水解鱼蛋白可能对代谢健康有有益影响。在这里，我们在一项双盲、随机干预研究中，以平行组设计调查了 8 周补充 4 克鳕鱼蛋白水解物（CPH）对 MetS 个体葡萄糖代谢、血脂谱和身体成分的影响。受试者每天接受 CPH（n = 15）或安慰剂（n = 15）补充。主要结局指标为血清空腹和餐后血糖水平。次要结局指标为空腹和餐后胰岛素和胰高血糖素样肽 1（GLP-1）、空腹血脂浓度和身体成分。8 周干预后，CPH 和安慰剂之间的胰岛素、葡萄糖或 GLP-1 没有差异。CPH 组和安慰剂组的空腹三酰甘油均降低，两组之间无差异。两组的空腹总胆固醇和低密度脂蛋白胆固醇均从基线显著下降，但两组之间无差异。总之，在 MetS 受试者中补充低剂量 CPH 8 周对空腹或餐后胰岛素、葡萄糖或 GLP-1、血脂谱或身体成分没有影响。
