Rogers J, Luber-Narod J, Styren S D, Civin W H
L. J. Roberts Center, Institute for Biogerontology Research, Sun City, AZ 85372.
Neurobiol Aging. 1988 Jul-Aug;9(4):339-49. doi: 10.1016/s0197-4580(88)80079-4.
HLA-DR is a class II major histocompatibility complex antigen which in the periphery confers antigen presenting capability. We have previously shown that this marker is profusely expressed in cortex of elderly and Alzheimer's disease (AD) patients, as is the receptor for the lymphokine interleukin-2. We now report presence of additional immune-related antigens in AD, and distributional differences from normal elderly controls. In gray matter, HLA-DR immunoreactivity is normally sparse, except in AD where it co-localizes with virtually all neuritic plaques. HLA-DR positive T cells can be demonstrated in Alzheimer's disease brain tissue, as can instances of apposition between putative brain microglia and T cells. In addition, cells with the morphologic characteristics of astrocytes label for natural killer cell antigen (Leu-11), and apparent lymphocytes bearing T helper and T cytotoxic/suppressor cell antigens are observed. These and other data suggest that the glial proliferation and scavenger activity characteristic of Alzheimer's disease may occur in an immune context and may play an important role in the pathogenesis of the disorder.
HLA - DR是一种II类主要组织相容性复合体抗原，在外周组织中具有抗原呈递能力。我们之前已经表明，该标志物在老年患者和阿尔茨海默病（AD）患者的皮质中大量表达，白细胞介素 - 2受体也是如此。我们现在报告AD中存在其他免疫相关抗原，以及与正常老年对照的分布差异。在灰质中，HLA - DR免疫反应性通常很少见，除了在AD中，它几乎与所有神经炎性斑块共定位。在阿尔茨海默病脑组织中可以证明HLA - DR阳性T细胞，以及假定的脑小胶质细胞与T细胞之间的并置情况。此外，具有星形胶质细胞形态特征的细胞标记为自然杀伤细胞抗原（Leu - 11），并且观察到带有T辅助细胞和T细胞毒性/抑制细胞抗原的明显淋巴细胞。这些以及其他数据表明，阿尔茨海默病特有的胶质细胞增殖和清除活性可能发生在免疫背景下，并且可能在该疾病的发病机制中起重要作用。
