Edris Noha A, Arfeen Shaimaa A, Mosaad Rana, Nassar Ghada A
Ophthalmology Department, Cairo University, Faculty of Medicine, Cairo, Egypt.
Dermatology Department, Cairo University, Faculty of Medicine, Cairo, Egypt.
Clin Ophthalmol. 2020 Jun 30;14:1833-1837. doi: 10.2147/OPTH.S256629. eCollection 2020.
To evaluate corneal biomechanical parameters with an ocular response analyzer (ORA) in patients with psoriasis and compare these parameters with age-matched control subjects.
This was a cross-sectional observational case-control study.
Thirty eyes of 15 psoriasis patients were included in the study and compared with 30 eyes of 15 control subjects. Corneal biomechanical properties were calculated by ORA. Central corneal thickness (CCT) was measured by anterior-segment optical coherence tomography. The main outcome measures were corneal hysteresis (CH), corneal resistance factor (CRF), corneal-compensated intraocular pressure (IOPcc), and Goldmann-correlated IOP (IOPg). For dry-eye evaluation, Schirmer's test was used.
Mean CH in the psoriasis group was 10.20±1.55 mmHg and in the control group 10.66±1.36 mmHg (=0.215). Mean CRF in the psoriasis group was 9.76±1.60 mmHg and in the control group 10.97±1.42 mmHg (=0.003). Mean IOPcc in the psoriasis group was 14.84±3.43 mmHg and in the control group 16.67±3.17 mmHg (=0.035). Mean IOPg in the psoriasis group was 13.92±3.35 mmHg and in the control group 16.62±3.10 mmHg (=0.002). Mean CCT in the psoriasis group was 543.90±37.27 µm and in the control group 551.23±28.63 µm (=0.392). Schirmer's test results in the psoriasis group were 11.4±1.57 mm/5 min and in the control group 17.5±1.52 mm/5 min (<0.001).
Psoriasis affects corneal biomechanical properties with statistically significantly lower corneal biomechanics than normal. CH correlates negatively with disease activity. These corneal biomechanical changes should be considered when determining IOP values and during corneal evaluation for keratoconus-suspected patients.
使用眼反应分析仪（ORA）评估银屑病患者的角膜生物力学参数，并将这些参数与年龄匹配的对照组受试者进行比较。
这是一项横断面观察性病例对照研究。
本研究纳入了15例银屑病患者的30只眼，并与15例对照受试者的30只眼进行比较。通过ORA计算角膜生物力学特性。采用眼前节光学相干断层扫描测量中央角膜厚度（CCT）。主要观察指标为角膜滞后（CH）、角膜阻力因子（CRF）、角膜补偿眼压（IOPcc）和Goldmann相关眼压（IOPg）。对于干眼评估，采用泪液分泌试验。
银屑病组的平均CH为10.20±1.55 mmHg，对照组为10.66±1.36 mmHg（P=0.215）。银屑病组的平均CRF为9.76±1.60 mmHg，对照组为10.97±1.42 mmHg（P=0.003）。银屑病组的平均IOPcc为14.84±3.43 mmHg，对照组为16.67±3.17 mmHg（P=0.035）。银屑病组的平均IOPg为13.92±3.35 mmHg，对照组为16.62±3.10 mmHg（P=0.002）。银屑病组的平均CCT为543.90±37.27 µm，对照组为551.23±28.63 µm（P=0.392）。银屑病组的泪液分泌试验结果为11.4±1.57 mm/5分钟，对照组为17.5±1.52 mm/5分钟（P<0.001）。
银屑病会影响角膜生物力学特性，其角膜生物力学在统计学上显著低于正常水平。CH与疾病活动度呈负相关。在确定眼压值以及对疑似圆锥角膜患者进行角膜评估时，应考虑这些角膜生物力学变化。
