Department of Dermatology, Hallym University Chuncheon Sacred Heart Hospital, Chunchon, Republic of Korea.
Jpn J Ophthalmol. 2013 Jul;57(4):341-6. doi: 10.1007/s10384-012-0226-4. Epub 2013 Mar 23.
To evaluate dry eye symptoms, tear film function and ocular surface changes in patients with psoriasis.
The Dry Eye Questionnaire and ophthalmic examination including the Schirmer test, tear break-up time, corneal fluorescein test, meibomian gland obstruction and conjunctival impression cytology were assessed in patients with chronic plaque psoriasis. Results were compared between 30 patients and 30 healthy controls.
The rate of positive responses in the Dry Eye Questionnaire and staining of corneal fluorescein test were significantly higher in the patients (P = 0.030) than in the controls (P = 0.012). The tear break-up time in patients was significantly lower than in the controls (P < 0.001). However, there were no differences in the Schirmer test and meibomian gland function between the patients and controls. In the impression cytology analysis, more cell alteration and decreased goblet cell density were observed in the patients (P < 0.001) compared with those obtained from controls (P = 0.003).
The dry eye symptom was more common in patients with psoriasis. In addition, the patients showed a higher tear film instability and significant degeneration on the ocular surface when compared with the normal controls.
评估银屑病患者的干眼症状、泪膜功能和眼表变化。
对 30 例慢性斑块状银屑病患者和 30 例健康对照者进行干眼问卷评估和眼科检查，包括泪液分泌试验、泪膜破裂时间、角膜荧光素染色、睑板腺功能障碍和结膜印迹细胞学检查。比较两组结果。
银屑病患者的干眼问卷阳性率和角膜荧光素染色评分显著高于对照组（P = 0.030；P = 0.012）。患者的泪膜破裂时间显著短于对照组（P < 0.001）。然而，两组的泪液分泌试验和睑板腺功能无差异。在印迹细胞学分析中，与对照组相比，患者的细胞形态改变更明显，杯状细胞密度降低（P < 0.001；P = 0.003）。
银屑病患者更常出现干眼症状。此外，与正常对照组相比，患者的泪膜稳定性较差，眼表有明显的退行性改变。
