Blaauw Jurre, Jacobs Bram, den Hertog Heleen M, van der Gaag Niels A, Jellema Korné, Dammers Ruben, Lingsma Hester F, van der Naalt Joukje, Kho Kuan H, Groen Rob J M
Department of Neurology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Center for Medical Decision Sciences, Department of Public Health, Erasmus Medical Center, Rotterdam, Netherlands.
Front Neurol. 2020 Jun 19;11:550. doi: 10.3389/fneur.2020.00550. eCollection 2020.
Surgery and specifically burr hole craniostomy is the most common first choice treatment of patients with Chronic Subdural Hematoma (CSDH). However, several aspects of neurosurgical and peri-operative management are still a subject of research, such as how to treat bilateral CSDH and the anesthetic approach. We aim to investigate the effect of the surgical approach to bilateral CSDH and the effect of anesthesia modality on outcome of CSDH patients. We retrospectively included surgically treated CSDH patients between 2005 and 2019 in three hospitals in the Netherlands. The effect of the surgical approach to bilateral CSDH (unilateral vs. bilateral decompression) and anesthesia modality (general vs. local anesthesia) on outcome (complications, recurrence, and length of hospital stay over 4 days) was studied with logistic regression adjusting for potentially confounding radiological and clinical characteristics. Data of 1,029 consecutive patients were analyzed, mean age was 73.5 years (±11) and 75% of patients were male. Bilateral CSDH is independently associated with an increased risk of recurrence within 3 months in logistic regression analysis (aOR 1.7, 95% CI: 1.1-2.5) but recurrence rate did not differ between primary bilateral or unilateral decompression of bilateral CSDH. (15 vs. 17%, = 0.775). Logistic regression analysis showed that general anesthesia was independently associated with an increased risk of complications (aOR 1.8, 95% CI: 1.0-3.3) and with a length of hospital admission of over 4 days (aOR 8.4, 95% CI: 5.6-12.4). Bilateral CSDH is independently associated with higher recurrence rates. As recurrence rates in bilateral CSDH are similar for different surgical approaches, the optimal choice for primary bilateral decompression of bilateral CSDH could vary per patient. General anesthesia for surgical treatment of CSDH is associated with higher complication rates and longer hospital admission.
手术,尤其是钻孔颅骨造口术,是慢性硬膜下血肿(CSDH)患者最常见的首选治疗方法。然而,神经外科和围手术期管理的几个方面仍是研究课题,比如如何治疗双侧CSDH以及麻醉方法。我们旨在研究双侧CSDH手术方式及麻醉方式对CSDH患者预后的影响。我们回顾性纳入了2005年至2019年期间荷兰三家医院接受手术治疗的CSDH患者。采用逻辑回归分析,对可能产生混淆的放射学和临床特征进行校正,研究双侧CSDH手术方式(单侧减压与双侧减压)及麻醉方式(全身麻醉与局部麻醉)对预后(并发症、复发及住院时间超过4天)的影响。分析了1029例连续患者的数据,平均年龄为73.5岁(±11岁),75%的患者为男性。在逻辑回归分析中,双侧CSDH与3个月内复发风险增加独立相关(调整后比值比1.7,95%置信区间:1.1 - 2.5),但双侧CSDH初次双侧减压或单侧减压的复发率并无差异(分别为15%和17%,P = 0.775)。逻辑回归分析显示,全身麻醉与并发症风险增加独立相关(调整后比值比1.8,95%置信区间:1.0 - 3.3),且与住院时间超过4天独立相关(调整后比值比8.4,95%置信区间:5.6 - 12.4)。双侧CSDH与较高的复发率独立相关。由于不同手术方式治疗双侧CSDH的复发率相似,双侧CSDH初次双侧减压的最佳选择可能因患者而异。CSDH手术治疗采用全身麻醉与较高的并发症发生率及更长的住院时间相关。