Pascu VÎnturiȘ Emilia Georgiana, GĂman Amelia Maria
University of Medicine and Pharmacy of Craiova, Romania.
Department of Hematology, Filantropia Municipal Hospital, Craiova, Romania.
Curr Health Sci J. 2020 Jan-Mar;46(1):23-30. doi: 10.12865/CHSJ.46.01.04. Epub 2020 Mar 31.
Oxidative stress (OS) implies an imbalance between the amount of tissue level of prooxidant and antioxidant compounds. It is involved in the pathophysiology of multiple pathological entities (neoplasms, disorders of carbohydrate and lipid metabolism, cardiovascular and renal pathology etc.), as well as in the pharmacokinetics of specific treatments for these pathologies. Chronic myeloid leukemia (CML) is a chronic myeloproliferative disease for which current standard treatment is BCR-ABL tyrosine kinase inhibitors (TKIs). It is known that OS is involved in CML pathogenesis and response to TKIs therapy, but in reality, there are a number of additional factors (associated comorbidities, specific therapies) that modulate oxidative status, possibly affecting the evolution and prognosis of CML. In the present paper we proposed the evaluation of OS in a group of patients with CML following treatment with TKIs, depending on the presence of comorbidities and associated treatments. There were considered associated comorbidities: diabetes mellitus, dyslipidemia, arterial hypertension, heart failure, chronic kidney disease. The variability of the oxidative status was found depending on the type of associated comorbidity, but also according to the associated treatment, with the possibility of producing drug interactions between the standard treatment of CML and the associated specific therapies. Their impact on the prognosis of CML patients in treatment with TKIs is not negligible and may represent a future research topic.
氧化应激（OS）意味着组织水平上促氧化剂和抗氧化剂化合物的量之间的失衡。它参与多种病理实体（肿瘤、碳水化合物和脂质代谢紊乱、心血管和肾脏疾病等）的病理生理学，以及这些疾病特定治疗的药代动力学。慢性粒细胞白血病（CML）是一种慢性骨髓增殖性疾病，目前的标准治疗方法是BCR-ABL酪氨酸激酶抑制剂（TKIs）。已知氧化应激参与慢性粒细胞白血病的发病机制以及对TKIs治疗的反应，但实际上，有许多其他因素（相关合并症、特定治疗）会调节氧化状态，可能影响慢性粒细胞白血病的进展和预后。在本文中，我们建议根据合并症和相关治疗的存在情况，对一组接受TKIs治疗的慢性粒细胞白血病患者进行氧化应激评估。考虑的相关合并症有：糖尿病、血脂异常、动脉高血压、心力衰竭、慢性肾脏病。发现氧化状态的变异性不仅取决于相关合并症的类型，还取决于相关治疗，慢性粒细胞白血病的标准治疗与相关特定治疗之间可能产生药物相互作用。它们对接受TKIs治疗的慢性粒细胞白血病患者预后的影响不可忽视，可能代表一个未来的研究课题。
