Metter E J, Riege W H, Hanson W R, Jackson C A, Kempler D, van Lancker D
National Institute of Aging, Gerontology Research Center, Baltimore, MD 21224.
Arch Neurol. 1988 Nov;45(11):1229-34. doi: 10.1001/archneur.1988.00520350067018.
Subcortical structural damage that includes the anterior and posterior internal capsule, caudate, thalamus, lenticular nuclei, and insula has been shown to cause aphasias. A critical question that has not been resolved is whether the role of these structures on behavior is a direct one or whether it is indirect through the cortex. We have used pathway analysis to evaluate computed tomography, glucose metabolic, and language data from 47 aphasic patients to answer this question. For fluency (from the Western Aphasia Battery), subcortical structural damage had direct and indirect (through frontal lobe) effects on the behavior. For a comprehension task (sequential commands), subcortical damage had no direct effect and only a slight indirect effect through the temporal lobe. Thus, both direct and indirect effects of subcortical damage can be demonstrated for specific behavioral measures.
包括前、后内囊、尾状核、丘脑、豆状核和岛叶在内的皮质下结构损伤已被证明会导致失语症。一个尚未解决的关键问题是，这些结构对行为的作用是直接的，还是通过皮层间接发挥作用。我们使用通路分析来评估47名失语症患者的计算机断层扫描、葡萄糖代谢和语言数据，以回答这个问题。对于流畅性（来自西方失语症成套测验），皮质下结构损伤对行为有直接和间接（通过额叶）影响。对于一项理解任务（顺序指令），皮质下损伤没有直接影响，仅通过颞叶有轻微的间接影响。因此，对于特定的行为测量，可以证明皮质下损伤的直接和间接影响。
