Karbe H, Kessler J, Herholz K, Fink G R, Heiss W D
Max-Planck-Institut für Neurologische Forschung, Köln, Germany.
Arch Neurol. 1995 Feb;52(2):186-90. doi: 10.1001/archneur.1995.00540260092022.
To evaluate positron emission tomography with the use of fludeoxyglucose F 18 as a predictor of the long-term outcome of poststroke aphasia.
Positron emission tomography shows functional deficits after stroke even in morphologically intact brain regions. The regional metabolic impairment can be related to the clinical deficit. Little is known about whether regional hypometabolism early after stroke predicts the long-term prognosis of stroke sequelae.
Twenty-two patients with language disturbance caused by a single lesion in the territory of the left middle cerebral artery were studied with fludeoxyglucose positron emission tomography and with a neuropsychological test battery that included a test of receptive language (Token Test) and a test of word fluency (/f/, /a/, /s/ test). The neuropsychological test was readministered about 2 years after the initial test.
Regional cerebral metabolic rates of glucose measured early after stroke showed a highly significant correlation with the results of the 2-year follow-up test. The receptive language disorder best correlated with cerebral metabolic rates of glucose in the left superior temporal cortex, and word fluency correlated with cerebral metabolic rates of glucose in the left prefrontal cortex.
Cerebral metabolic rates of glucose in speech-relevant brain regions measured early after stroke are a predictor of the eventual outcome of aphasia.
评估使用氟脱氧葡萄糖F 18进行正电子发射断层扫描作为中风后失语症长期预后的预测指标。
正电子发射断层扫描显示，即使在形态学上完整的脑区，中风后也存在功能缺陷。区域代谢损害可能与临床缺陷有关。关于中风后早期区域代谢减低是否能预测中风后遗症的长期预后，目前知之甚少。
对22例因左侧大脑中动脉供血区单个病灶导致语言障碍的患者进行了氟脱氧葡萄糖正电子发射断层扫描，并使用一套神经心理测试组合进行评估，该组合包括一项接受性语言测试（代币测试）和一项词汇流畅性测试（/f/、/a/、/s/测试）。在初次测试约2年后再次进行神经心理测试。
中风后早期测量的区域脑葡萄糖代谢率与2年随访测试结果显示出高度显著的相关性。接受性语言障碍与左侧颞上回皮质的脑葡萄糖代谢率相关性最佳，词汇流畅性与左侧前额叶皮质的脑葡萄糖代谢率相关。
中风后早期测量的与言语相关脑区的脑葡萄糖代谢率是失语症最终预后的预测指标。
