Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Dev Cell. 2020 Jul 20;54(2):183-195. doi: 10.1016/j.devcel.2020.06.018. Epub 2020 Jul 7.
Solid tumors reside in harsh tumor microenvironments (TMEs) together with various stromal cell types. During tumor progression and metastasis, both tumor and stromal cells undergo rapid metabolic adaptations. Tumor cells metabolically coordinate or compete with their "neighbors" to maintain biosynthetic and bioenergetic demands while escaping immunosurveillance or therapeutic interventions. Here, we provide an update on metabolic communication between tumor cells and heterogeneous stromal components in primary and metastatic TMEs and discuss emerging strategies to target metabolic communications for improved cancer treatments.
实体瘤与各种基质细胞类型一起存在于恶劣的肿瘤微环境 (TME) 中。在肿瘤进展和转移过程中，肿瘤细胞和基质细胞都会经历快速的代谢适应。肿瘤细胞通过代谢协调或与“邻居”竞争来维持生物合成和生物能量需求，同时逃避免疫监视或治疗干预。在这里，我们提供了关于原发性和转移性 TME 中肿瘤细胞和异质基质成分之间代谢通讯的最新信息，并讨论了为改善癌症治疗而靶向代谢通讯的新兴策略。
