Department of Chemistry and the Beckman Institute, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, United States.
Department of Chemistry and the Beckman Institute, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, United States.
Biochim Biophys Acta Proteins Proteom. 2020 Nov;1868(11):140482. doi: 10.1016/j.bbapap.2020.140482. Epub 2020 Jul 5.
d-Alanine (d-Ala) is an unusual endogenous amino acid present in invertebrates and vertebrates. Compared to its l-isomer, the characterization of d-Ala is challenging because of the need for chiral resolution and the low amounts of the d-enantiomer present. With recent improvements in measurement capabilities, research on d-Ala, along with other d-amino acids, has been growing, especially as the functional significance of d-Ala in the mammalian nervous and endocrine systems is becoming known. Here we provide an overview of the distribution, origin, function, and disease implications of d-Ala.
d-丙氨酸（d-Ala）是一种存在于无脊椎动物和脊椎动物中的非寻常内源性氨基酸。与它的 l-异构体相比，由于需要手性拆分和低含量的 d-对映异构体，d-Ala 的特征描述具有挑战性。随着测量能力的最新提高，对 d-Ala 以及其他 d-氨基酸的研究一直在增长，特别是因为 d-Ala 在哺乳动物神经系统和内分泌系统中的功能意义变得众所周知。在这里，我们提供了 d-Ala 的分布、来源、功能和疾病影响的概述。
