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Curcumin: a Wonder Drug as a Preventive Measure for COVID19 Management.姜黄素：一种作为新冠病毒管理预防措施的神奇药物。
Indian J Clin Biochem. 2020 Jul;35(3):373-375. doi: 10.1007/s12291-020-00902-9. Epub 2020 Jun 17.
2
Influence of particle size on the in vitro and in vivo anti-inflammatory and anti-allergic activities of a curcumin lipid nanoemulsion.姜黄素脂质纳米乳剂的粒径对其体外和体内抗炎及抗过敏活性的影响。
Int J Mol Med. 2015 Jun;35(6):1720-8. doi: 10.3892/ijmm.2015.2186. Epub 2015 Apr 16.
3
Curcumin nanoemulsion for transdermal application: formulation and evaluation.用于透皮给药的姜黄素纳米乳剂：制剂与评价
Drug Dev Ind Pharm. 2015 Apr;41(4):560-6. doi: 10.3109/03639045.2014.884127. Epub 2014 Feb 7.
4
Formulation and physiochemical study of α-tocopherol based oil in water nanoemulsion stabilized with non toxic, biodegradable surfactant: Sodium stearoyl lactate.α-生育酚油在水中纳米乳的配方及理化性质研究：以无毒、可生物降解的表面活性剂——硬脂酰乳酸钠稳定。
Ultrason Sonochem. 2017 Sep;38:570-578. doi: 10.1016/j.ultsonch.2016.08.026. Epub 2016 Aug 20.
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Drug-loaded nanoemulsion as positive control is an alternative to DMSO solutions for in vitro evaluation of curcumin delivery to MCF-7 cells.载药纳米乳作为阳性对照，可替代 DMSO 溶液，用于 MCF-7 细胞中姜黄素传递的体外评价。
Pharmacol Rep. 2017 Dec;69(6):1408-1412. doi: 10.1016/j.pharep.2017.05.003. Epub 2017 May 11.
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Spray-dried curcumin nanoemulsion: A new road to improvement of oral bioavailability of curcumin.喷雾干燥姜黄素纳米乳剂：提高姜黄素口服生物利用度的新途径。
Pak J Pharm Sci. 2018 Jan;31(1):169-173.
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In Vitro Study on Antihypertensive and Antihypercholesterolemic Effects of a Curcumin Nanoemulsion.姜黄素纳米乳剂的降压和降胆固醇作用的体外研究
Sci Pharm. 2016 Feb 14;84(1):131-40. doi: 10.3797/scipharm.ISP.2015.05. Print 2016 Jan-Mar.
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Effect of Curcumin-Nanoemulsion Associated with Photodynamic Therapy in Cervical Carcinoma Cell Lines.姜黄素纳米乳联合光动力疗法对宫颈癌细胞系的影响。
Biomed Res Int. 2018 Jan 17;2018:4057959. doi: 10.1155/2018/4057959. eCollection 2018.
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Development of Curcumin loaded chitosan polymer based nanoemulsion gel: In vitro, ex vivo evaluation and in vivo wound healing studies.负载姜黄素的壳聚糖聚合物基纳米乳液凝胶的研制：体外、离体评价及体内伤口愈合研究
Int J Biol Macromol. 2017 Aug;101:569-579. doi: 10.1016/j.ijbiomac.2017.03.066. Epub 2017 Mar 16.
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Antiviral Action of Curcumin Encapsulated in Nanoemulsion against Four Serotypes of Dengue Virus.纳米乳剂包封的姜黄素对四种登革病毒血清型的抗病毒作用
Pharm Nanotechnol. 2020;8(1):54-62. doi: 10.2174/2211738507666191210163408.

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Identification of Significant Mutations in Spike Protein of SARS-CoV-2 Variants of Concern and the Discovery of Potent Inhibitors.关注的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变体刺突蛋白中显著突变的鉴定及强效抑制剂的发现
Glob Health Epidemiol Genom. 2025 Apr 28;2025:5042190. doi: 10.1155/ghe3/5042190. eCollection 2025.
2
Evaluation of curcumin-loaded chitosan nanoparticles for wound healing activity.负载姜黄素的壳聚糖纳米粒伤口愈合活性评估
ADMET DMPK. 2023 Aug 25;11(4):601-613. doi: 10.5599/admet.1897. eCollection 2023.
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The Use of D-Optimal Mixture Design in Optimizing Formulation of a Nutraceutical Hard Candy.D-最优混合设计在优化营养硬糖配方中的应用
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Comparative docking studies of drugs and phytocompounds for emerging variants of SARS-CoV-2.针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）新出现变体的药物和植物化合物的比较对接研究。
3 Biotech. 2023 Jan;13(1):36. doi: 10.1007/s13205-022-03450-6. Epub 2023 Jan 5.
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Role of Dantabija, Haridra, and Zingiber (DHZ) combination to restore health and immunity in mild to moderate COVID-19 patients.丹塔比贾、姜黄和姜（DHZ）组合在轻至中度新冠肺炎患者恢复健康和免疫力方面的作用。
J Family Med Prim Care. 2022 Oct;11(10):6067-6073. doi: 10.4103/jfmpc.jfmpc_453_22. Epub 2022 Oct 31.
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Strategies for Improving Bioavailability, Bioactivity, and Physical-Chemical Behavior of Curcumin.提高姜黄素生物利用度、生物活性和物理化学行为的策略。
Molecules. 2022 Oct 13;27(20):6854. doi: 10.3390/molecules27206854.
7
Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?营养保健品对新冠病毒感染及新冠康复后的预防和治疗有效吗？
Foods. 2022 Sep 17;11(18):2884. doi: 10.3390/foods11182884.
8
Natural therapeutics against SARS CoV2: the potentiality and challenges.针对新型冠状病毒2的天然疗法：潜力与挑战。
Vegetos. 2023;36(2):322-331. doi: 10.1007/s42535-022-00401-7. Epub 2022 Jun 15.
9
The effect of curcumin on the risk of mortality in patients with COVID-19: A systematic review and meta-analysis of randomized trials.姜黄素对COVID-19患者死亡风险的影响：一项随机试验的系统评价和荟萃分析。
Phytother Res. 2022 Sep;36(9):3365-3368. doi: 10.1002/ptr.7468. Epub 2022 Apr 28.
10
Molecular Docking and Molecular Dynamics Simulations Discover Curcumin Analogue as a Plausible Dual Inhibitor for SARS-CoV-2.分子对接和分子动力学模拟发现姜黄素类似物可作为 SARS-CoV-2 的合理双抑制剂。
Int J Mol Sci. 2022 Feb 4;23(3):1771. doi: 10.3390/ijms23031771.

本文引用的文献

1
An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study.利用分子对接研究鉴定 SARS-CoV-2 主蛋白酶潜在抑制剂的研究。
J Biomol Struct Dyn. 2021 Jun;39(9):3347-3357. doi: 10.1080/07391102.2020.1763201. Epub 2020 May 13.
2
Treatment options for COVID-19: The reality and challenges.治疗 COVID-19 的选择：现实与挑战。
J Microbiol Immunol Infect. 2020 Jun;53(3):436-443. doi: 10.1016/j.jmii.2020.03.034. Epub 2020 Apr 4.
3
Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.血管紧张素转换酶2（ACE2）作为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的受体：分子机制与潜在治疗靶点
Intensive Care Med. 2020 Apr;46(4):586-590. doi: 10.1007/s00134-020-05985-9. Epub 2020 Mar 3.
4
Effects of Phytochemicals on Blood Pressure and Neuroprotection Mediated Via Brain Renin-Angiotensin System.植物化学物质通过脑肾素-血管紧张素系统对血压和神经保护的影响。
Nutrients. 2019 Nov 14;11(11):2761. doi: 10.3390/nu11112761.
5
Anti-infective Properties of the Golden Spice Curcumin.金色香料姜黄素的抗感染特性
Front Microbiol. 2019 May 3;10:912. doi: 10.3389/fmicb.2019.00912. eCollection 2019.
6
Curcumin inhibits angiotensin II-induced inflammation and proliferation of rat vascular smooth muscle cells by elevating PPAR-γ activity and reducing oxidative stress.姜黄素通过提高PPAR-γ活性和降低氧化应激来抑制血管紧张素II诱导的大鼠血管平滑肌细胞炎症和增殖。
Int J Mol Med. 2017 May;39(5):1307-1316. doi: 10.3892/ijmm.2017.2924. Epub 2017 Mar 20.
7
In Vitro Study on Antihypertensive and Antihypercholesterolemic Effects of a Curcumin Nanoemulsion.姜黄素纳米乳剂的降压和降胆固醇作用的体外研究
Sci Pharm. 2016 Feb 14;84(1):131-40. doi: 10.3797/scipharm.ISP.2015.05. Print 2016 Jan-Mar.
8
Attenuation of myocardial fibrosis with curcumin is mediated by modulating expression of angiotensin II AT1/AT2 receptors and ACE2 in rats.姜黄素对大鼠心肌纤维化的减轻作用是通过调节血管紧张素II AT1/AT2受体和ACE2的表达来介导的。
Drug Des Devel Ther. 2015 Nov 11;9:6043-54. doi: 10.2147/DDDT.S95333. eCollection 2015.
9
ACE2 of the heart: From angiotensin I to angiotensin (1-7).心脏中的血管紧张素转换酶2：从血管紧张素I到血管紧张素（1-7）。
Cardiovasc Res. 2007 Feb 1;73(3):463-9. doi: 10.1016/j.cardiores.2006.09.006. Epub 2006 Sep 19.
10
ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia.血管紧张素转换酶2（ACE2）受体表达与严重急性呼吸综合征冠状病毒感染取决于人呼吸道上皮细胞的分化。
J Virol. 2005 Dec;79(23):14614-21. doi: 10.1128/JVI.79.23.14614-14621.2005.

Curcumin: a Wonder Drug as a Preventive Measure for COVID19 Management.

作者信息

Manoharan Yamuna, Haridas Vikram, Vasanthakumar K C, Muthu Sundaram, Thavoorullah Fathima F, Shetty Praveenkumar

机构信息

Winomicx Molecular Diagnostics and Research (P) Ltd, Golden Jubilee Biotech Park for Women society, 4th Main Road, 2nd Cross Road, Inside SIPCOT-IT Park Old Mahabalipuram Road Navalur, Chennai, Tamil Nadu 603103 India.

Arthritis Speciality Center, Harsha Complex, Market Road, Surathkal, Hubli, Karnataka 575014 India.

出版信息

Indian J Clin Biochem. 2020 Jul;35(3):373-375. doi: 10.1007/s12291-020-00902-9. Epub 2020 Jun 17.

DOI:10.1007/s12291-020-00902-9
PMID:32641876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7299138/
Abstract
摘要