Grundy Emily J, Suddek Taiba, Filippidis Filippos T, Majeed Azeem, Coronini-Cronberg Sophie
Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom.
Department of Paediatrics, Imperial College Healthcare NHS Trust, London, United Kingdom.
Tob Induc Dis. 2020 Jul 3;18:58. doi: 10.18332/tid/124788. eCollection 2020.
There has been significant speculation regarding the association between the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pathogen, coronavirus disease (COVID-19) and smoking. We provide an overview of the available literature regarding the association between smoking, risk of SARS-CoV-2 infection, and risk of severe COVID-19 and poor clinical outcomes, with the aim of informing public health policy and practice, particularly in England.
Publications were identified utilising a systematic search approach on PUBMED and Google Scholar. Publications presenting a systematic review or meta-analysis considering the association between smoking and SARS-COV-2 infection or COVID-19 outcomes were included.
Eight studies were identified. One considered the relationship between smoking and the probability of SARS-CoV-2 infection, three considered the association between COVID-19 hospitalisation and smoking history, and six reviewed the association between smoking history and development of severe COVID-19. One study specifically investigated the risk of mortality. The studies considering risk of severe disease indicate that there is a significant association between COVID-19 and current or ever smoking.
This is a rapidly evolving topic. Current analysis remains limited due to the quality of primary data, although, early results indicate an association between smoking and COVID-19 severity. We highly recommend public health messaging to continue focusing on smoking cessation efforts.
关于严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病原体、冠状病毒病（COVID-19）与吸烟之间的关联，一直存在大量猜测。我们概述了现有关于吸烟、SARS-CoV-2感染风险、严重COVID-19风险及不良临床结局之间关联的文献，目的是为公共卫生政策和实践提供信息，特别是在英格兰。
通过对PUBMED和谷歌学术进行系统检索来识别出版物。纳入了呈现关于吸烟与SARS-CoV-2感染或COVID-19结局之间关联的系统评价或荟萃分析的出版物。
共识别出八项研究。一项研究考虑了吸烟与SARS-CoV-2感染可能性之间的关系，三项研究考虑了COVID-19住院与吸烟史之间的关联，六项研究回顾了吸烟史与严重COVID-19发展之间的关联。一项研究专门调查了死亡率风险。考虑严重疾病风险的研究表明，COVID-19与当前吸烟或曾经吸烟之间存在显著关联。
这是一个快速发展的主题。由于原始数据质量的原因，当前分析仍然有限，尽管早期结果表明吸烟与COVID-19严重程度之间存在关联。我们强烈建议公共卫生宣传继续专注于戒烟努力。
